Female Genital Disorder as Adverse Symptom of Lamotrigine Treatment
Female Genital Disorder as Adverse Symptom of Lamotrigine Treatment
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DOI：
10.1159/000026538
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发表时间：
1998-10
影响因子：
3.2
通讯作者：
A. Erfurth;B. Amann;H. Grunze
中科院分区：
文献类型：
--
作者：
A. Erfurth;B. Amann;H. Grunze
新的抗惊厥药拉莫三嗪正在成为治疗双相情感障碍（包括双相抑郁）的重要工具。它在双相抑郁症中的疗效可能与其抑制血清素摄取有关。我们提出的情况下，成功地与400毫克的拉莫三嗪发展相当的生殖器疾病，副作用众所周知的选择性5-羟色胺再摄取抑制剂（SSRIs）治疗的女性embryoaffective患者。我们认为，高剂量拉莫三嗪引起的女性生殖器疾病是一种胆碱能副作用。
The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake. We present the case of a female schizoaffective patient successfully treated with 400 mg of lamotrigine developing considerable genital disorder, a side effect well known from the treatment with selective serotonin reuptake inhibitors (SSRIs). We suggest that female genital disorder induced by high doses of lamotrigine is a serotoninergic side effect.