Subjective and neurovegetative changes in healthy volunteers and panic patients performing simulated public speaking
Subjective and neurovegetative changes in healthy volunteers and panic patients performing simulated public speaking
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DOI：
10.1016/j.euroneuro.2005.05.002
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发表时间：
2005-12-01
影响因子：
5.6
通讯作者：
Graeff, FG
中科院分区：
文献类型：
--
作者：
Parente, ACBV;Garcia-Leal, C;Graeff, FG
没有药物的症状性惊恐患者、药物治疗的无症状性惊恐患者和健康对照组接受模拟公开演讲。在实验开始时，有症状患者的主观焦虑、认知障碍和不适(由视觉模拟情绪量表测量)以及皮肤电导水平高于对照组，无症状患者介于两者之间。三组的主观镇静、皮肤电导、心率和血压的自发波动相似。演讲的准备和练习减少了镇静，同时增加了焦虑、认知障碍、皮肤电导、心率和血压的水平和波动。有症状的患者焦虑、认知障碍和电导水平较对照组增加较少。皮肤电活动，而不是交感觉醒的心血管指标与预期焦虑相关。5-羟色胺摄取抑制剂的长期治疗减少了恐慌症患者和对照组之间的差异，支持5-羟色胺参与了恐慌症。(C)2005年爱思唯尔和ECNP。版权所有。
Drug-free symptomatic panic patients, drug-treated nonsymptomatic patients and healthy controls were submitted to simulated public speaking. Subjective anxiety, cognitive impairment and discomfort measured by the visual analog mood scale as well as skin conductance level were higher in symptomatic patients than in controls at the beginning of the experimental session, nonsymptomatic patients lying in between. Subjective sedation, spontaneous fluctuations of skin conductance, heart rate and blood pressure were similar in the three groups. Preparation and performance of speech decreased sedation while increasing anxiety, cognitive impairment, level and fluctuations of skin conductance, heart rate and blood pressure. Anxiety, cognitive impairment and conductance level were less increased in symptomatic patients than in controls. Electrodermal activity, but not cardiovascular measures of sympathetic arousal correlated with anticipatory anxiety. Chronic treatment with serotonin uptake inhibitors attenuated the differences between panic patients and controls, supporting the participation of serotonin in panic disorder. (c) 2005 Elsevier B.V. and ECNP. All rights reserved.