The Role of Mucosal Microbiota in the Development, Maintenance, and Pathologies of the Mucosal Immune System
The Role of Mucosal Microbiota in the Development, Maintenance, and Pathologies of the Mucosal Immune System
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DOI：
10.1016/b978-012491543-5/50022-x
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发表时间：
2005
影响因子：
8
通讯作者：
Tlaskalova-Hogenova H
中科院分区：
文献类型：
--
作者：
Cebra JJ;Jiang HQ;Boiko N;Tlaskalova-Hogenova H
淋巴系统的肥大和炎症状态有所逆转，但几乎没有关于免疫系统特定成分的发育状况和功能活动的影响的信息。然而，许多关于肠道微生物在GF或AF小鼠体内的定植和新生儿自然定植对系统免疫系统影响的分析可以概括如下(见Cebra等人，1999，更详细的说明)。常规饲养(CNV)新生儿在脾和外周淋巴结(PLN)中形成“天然”空斑形成细胞(PFC)或抗体分泌细胞(ASC)，对抗自身抗原、细菌抗原(尤其是脂多糖[LPS])和绵羊红细胞(SRBC)，而GF新生儿在这种发育中非常迟缓(Tlaskalova等人，1970,1983；Tlaskalova和Stepankova，1980)。
18 state of hypertrophy and inflammation of the lymphoid system is somewhat reversed but there is little information of the effects on the developmental status and functional activity of particular elements of the immune system. However, the many analyses of the effects of intestinal colonization with microbes of GF or AF mice and of natural colonization of neonates on the systemic immune system can be generalized as follows (see Cebra et al., 1999, for a more detailed account).Conventionally reared (CNV) neonates develop “natural” plaque-forming cells (PFC) or antibody-secreting cells (ASC) in spleen and peripheral lymph nodes (PLN) against autoantigens, bacterial antigens (Ags)(especially lipopolysaccharide [LPS]), and sheep red blood cells (SRBC), whereas GF neonates are greatly retarded in this development (Tlaskalova et al., 1970, 1983; Tlaskalova and Stepankova, 1980).