Polymorphisms of renin-angiotensin genes among Nigerians, Jamaicans, and African Americans.
Polymorphisms of renin-angiotensin genes among Nigerians, Jamaicans, and African Americans.
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尼日利亚人、牙买加人和非裔美国人中肾素-血管紧张素基因的多态性。
DOI：
10.1161/01.hyp.27.3.558
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Ward,R
中科院分区：
文献类型：
--
作者：
Rotimi,C;Puras,A;Cooper,R;McFarlane-Anderson,N;Forrester,T;Ogunbiyi,O;Morrison,L;Ward,R
在一项国际合作研究的背景下，高血压的演变在黑人散居地，我们确定了高血压候选基因的等位基因分布的肾素-血管紧张素系统在三个非洲裔人口。血管紧张素转换酶（ACE）和血管紧张素原（AGT）基因的M235 T和T174 M变体的插入/缺失（I/D）多态性进行了检查，在个人从尼日利亚，牙买加和美国。在挨家挨户的调查中，高血压的患病率有很大的差异，从尼日利亚的16%到美国的33%。D等位基因的频率在所有人群中相似（在尼日利亚、牙买加和美国分别为54%、59%和63%）。81%的美国和牙买加黑人以及91%的尼日利亚人中发现了AGT基因的235 T等位基因; T174 M标记的变化很小。尽管高血压发病率存在很大差异，但这些群体之间指数位点的遗传变异是适度的。总的来说，ACE ★D等位基因的频率仅略高于欧洲和日本人群，而AGT 235 T等位基因的频率是欧洲和日本人群的两倍。与西半球的黑人相比，牙买加人的235 T等位基因频率更高，这与牙买加和美国25%的欧洲混血儿一致。结果表明，潜在的病因异质性的遗传因素相关的高血压跨种族群体，同时表明，环境暴露最有可能解释的风险梯度在黑人人群之间的比较。
Within the context of an international collaborative study of the evolution of hypertension in the black diaspora, we determined the allelic distribution of hypertension candidate genes for the renin-angiotensin system in three populations of African origin. The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) and the M235T and T174M variants of the angiotensinogen(AGT)gene were examined in individuals from Nigeria, Jamaica, and the United States. Large differences in the prevalence of hypertension were recorded in door-to-door surveys, ranging from 16% in Nigeria to 33% in the United States. The frequency of theDallele was similar in all groups (54%, 59%, and 63% in Nigeria, Jamaica, and the United States, respectively). The 235T allele of theAGTgene was found in 81% of US and Jamaican blacks and 91% of Nigerians; very little variation was seen for the T174M marker. Despite large differences in hypertension rates, genetic variation at the index loci among these groups was modest. Overall, the frequency of theACE★D allele was only slightly higher than that reported for European and Japanese populations, whereas theAGT235T allele was twice as common. Compared with blacks in the western hemisphere, Nigerians had a higher frequency of the 235T allele, which is consistent with 25% European admixture in Jamaica and the United States. The results indicate the potential for etiologic heterogeneity in genetic factors related to hypertension across ethnic groups while suggesting that environmental exposures most likely explain the gradient in risk in the comparison among black populations.