SCOPE AND STEREOCHEMICAL COURSE OF THE ADDITION OF (TRIMETHYLSILYL)ALLENES TO KETONES AND ALDEHYDES - A REGIOCONTROLLED SYNTHESIS OF HOMOPROPARGYLIC ALCOHOLS
SCOPE AND STEREOCHEMICAL COURSE OF THE ADDITION OF (TRIMETHYLSILYL)ALLENES TO KETONES AND ALDEHYDES - A REGIOCONTROLLED SYNTHESIS OF HOMOPROPARGYLIC ALCOHOLS
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DOI：
10.1021/jo00370a023
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发表时间：
1986-10-03
影响因子：
3.6
通讯作者：
KWASIGROCH, CA
中科院分区：
文献类型：
--
作者：
DANHEISER, RL;CARINI, DJ;KWASIGROCH, CA
(3)发现所有三种类型（I、II和III）的炔丙醇通过在四氯化钛存在下（三甲基甲硅烷基）联烯与酮和醛的区域特异性加成而容易获得。在本文中，我们现在提供我们的调查，这一反应的范围的全部细节。进一步的例子的方法进行了描述，包括几个新的情况下，涉及手性alienes定义的立体化学过程中的反应。
(3) propargylic alcohols of all three types (I, II, and III) were found to be readily available via the regiospecific addition of (trimethylsilyl) allenesto ketones and aldehydes in the presence of titanium tetrachloride. In this paper we now provide full details of our investigation of the scope of this reaction. Further examples of the method are described, including several new cases involving chiral alienes which define the stereochemical course of the reaction.