Association between apoptosis inhibitor of macrophage and microsatellite instability status in colorectal cancer.
Association between apoptosis inhibitor of macrophage and microsatellite instability status in colorectal cancer.
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DOI：
10.1186/s12876-020-01520-8
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发表时间：
2020-11-10
影响因子：
2.4
通讯作者：
Wang RT
中科院分区：
文献类型：
--
作者：
Huang WJ;Wang X;Zhang ML;Li L;Wang RT
结直肠癌（CRC）的微卫星不稳定性（MSI）比微卫星稳定性（MSS）肿瘤具有更有利的临床结果，其特点是各种免疫检查点的表达高度上调。巨噬细胞凋亡抑制剂（Apoptosis inhibitor of macrophage， AIM）是一种循环蛋白，在全身循环清除细胞碎片。本研究的目的是评估CRC患者MSI状态与aim水平之间的关系。在这项研究中，我们用酶联免疫吸附试验（ELISA）评估了430例结直肠癌患者血清中AIM的水平。收集所有患者初诊时的临床和实验室特征。研究了AIM水平与MSI状态之间的关系。64例（14.9%）被确定为MSI- h（高频MSI）， 366例（85.1%）被确定为MSS。与MSS患者相比，MSI-H表型患者的AIM水平较低。此外，AIM水平与组织学类型和MSI状态相关。Logistic回归分析显示，调整混杂因素后，AIM水平下降与MSI-H表型独立相关。降低的AIM水平与CRC的MSI-H亚型相关。需要进一步研究AIM在MSI-H CRC中的作用。
The microsatellite instability (MSI) in colorectal cancer (CRC) has a more favorable clinical outcome and is characterized by highly upregulated expression of various immunological checkpoints than microsatellite stable (MSS) tumors. Apoptosis inhibitor of macrophage (AIM) is a circulating protein and circulates throughout the body to remove cellular debris. The aim of this study was to evaluate the association between MSI status and AIM levels in CRC patients. In this study, we evaluated the levels of AIM by Enzyme Linked Immuno-Sorbent Assay (ELISA) in serum of 430 CRC patients. All patients’ clinical and laboratory characteristics at initial diagnosis were collected. The relationship between AIM levels and MSI status was examined. 64 patients (14.9%) were identified as having MSI-H (high-frequency MSI) and 366 casess (85.1%) having MSS. Patients with an MSI-H phenotype had lower AIM levels compared with MSS patients. Moreover, AIM levels were correlated with histological type and MSI status. Logistic regression analysis revealed that decreased AIM levels were independently associated with MSI-H phenotype after adjusting confounding factors. Reduced AIM levels are associated with MSI-H subtyping of CRC. Further research on the involvement of AIM in MSI-H CRC is needed.
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影响因子：
2.4
作者：
Mera K;Uto H;Mawatari S;Ido A;Yoshimine Y;Nosaki T;Oda K;Tabu K;Kumagai K;Tamai T;Moriuchi A;Oketani M;Shimada Y;Hidaka M;Eguchi S;Tsubouchi H
通讯作者：
Tsubouchi H
CD8 T 细胞在免疫性血小板减少症中通过血小板脱唾液酸作用诱导肝脏中的血小板清除
影响因子：
4.6
作者：
Qiu J;Liu X;Li X;Zhang X;Han P;Zhou H;Shao L;Hou Y;Min Y;Kong Z;Wang Y;Wei Y;Liu X;Ni H;Peng J;Hou M
通讯作者：
Hou M
评估巨噬细胞凋亡抑制剂/CD5L 作为预测脓毒症危重患者死亡率的生物标志物
影响因子：
9.6
作者：
Gao, Xun;Liu, Yi;Cao, Ju
通讯作者：
Cao, Ju
影响因子：
6.4
作者：
Cassetta L;Kitamura T
通讯作者：
Kitamura T
影响因子：
4
作者：
Dehnel, Nathalie;Moral, Javier;Bruenet, Bernhard
通讯作者：
Bruenet, Bernhard