Stromal Modulators of TGF-β in Cancer.
Stromal Modulators of TGF-β in Cancer.
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DOI：
10.3390/jcm6010007
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发表时间：
2017-01-06
影响因子：
3.9
通讯作者：
Turtoi A
中科院分区：
文献类型：
--
作者：
Costanza B;Umelo IA;Bellier J;Castronovo V;Turtoi A
转化生长因子-β（Transforming growth factor-β，TGF-β）是一种在恶性肿瘤中具有双重活性的细胞因子。它一方面是肿瘤侵袭、转移和血管生成的重要介质，另一方面也表现出抗肿瘤功能。阐明TGF-β在恶性肿瘤发生和发展中的确切作用需要更好地理解其肿瘤抑制因子向肿瘤促进因子转换的分子机制。TGF-β功能的一个重要方面是其与肿瘤微环境中的蛋白质的相互作用。几种基质蛋白具有相互作用和调节TGF-β功能的天然能力。了解TGF-β信号网络和这些基质蛋白之间的复杂相互作用可能会为靶向TGF-β轴的新型治疗策略的开发提供更深入的了解。本综述强调了我们目前对基质如何调节人类癌症中TGF-β活性的理解。
Transforming growth factor-β (TGF-β) is an intriguing cytokine exhibiting dual activities in malignant disease. It is an important mediator of cancer invasion, metastasis and angiogenesis, on the one hand, while it exhibits anti-tumor functions on the other hand. Elucidating the precise role of TGF-β in malignant development and progression requires a better understanding of the molecular mechanisms involved in its tumor suppressor to tumor promoter switch. One important aspect of TGF-β function is its interaction with proteins within the tumor microenvironment. Several stromal proteins have the natural ability to interact and modulate TGF-β function. Understanding the complex interplay between the TGF-β signaling network and these stromal proteins may provide greater insight into the development of novel therapeutic strategies that target the TGF-β axis. The present review highlights our present understanding of how stroma modulates TGF-β activity in human cancers.