Treatment of neutropenic infection: trends towards monotherapy?
Treatment of neutropenic infection: trends towards monotherapy?
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中性粒细胞减少感染的治疗：单一疗法的趋势？
DOI：
10.1007/s005200050093
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发表时间：
1997
影响因子：
3.1
通讯作者：
J. Klastersky
中科院分区：
文献类型：
--
作者：
J. Klastersky
在过去的20年里，发热性中性粒细胞减少症是一种不断变化的综合征。我们今天面临的前景和目标主要是不断调整抗菌预防和治疗方案以适应耐药菌株的出现;影响发热性中性粒细胞减少症预后因素的定义;引入实用的适应性治疗算法;某些类别患者的门诊和/或家庭治疗;使用细胞因子恢复早期骨髓功能和帮助发热性中性粒细胞减少症的家庭管理的适应症的定义，最后，认识真菌感染的危险因素，改进我们的诊断和治疗抗真菌策略。
Febrile neutropenia has been a changing syndrome over the last 20 years. The perspectives and goals that we face today are mainly the constant adaptation of antibacterial prophylactic and therapeutic regimens to the emergence of resistant strains; the definition of prognostic factors influencing the outcome of febrile neutropenia; the introduction of pragmatic algorithms for adaptation of therapy; ambulatory and/or home therapy for certain categories of patients; the definition of indications for the use of cytokines to restore earlier bone marrow function and to help with home management of febrile neutropenia, and, finally, the recognition of risk factors for fungal infections and the improvement of our diagnostic as well as therapeutic anti-fungal strategies.