Serum testosterone levels and breast cancer recurrence
Serum testosterone levels and breast cancer recurrence
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DOI：
10.1002/ijc.20582
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发表时间：
2005-01-20
影响因子：
6.4
通讯作者：
Secreto, G
中科院分区：
文献类型：
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作者：
Berrino, F;Pasanisi, P;Secreto, G
前瞻性研究表明，高血清雄激素和雌激素水平与绝经后乳腺癌发病率增加有关。本分析的目的是研究血清睾酮、雌二醇及其相关因素对绝经后乳腺癌患者的预后价值。110例无临床复发的患者纳入研究。随访5.5年后，31例患者发生远处转移（16例）、局部复发（4例）或对侧乳腺癌（11例）。通过考克斯比例风险模型，调整激素受体状态和诊断时的分期，检查与激素水平相关的不良事件风险。复发患者的体重指数和血清睾酮、雌二醇和葡萄糖水平显著高于未复发患者。基线睾酮分布的中三分位数和上三分位数的风险比分别为1.8（95% CI = 0.5- 6.3）和7.2（95% CI = 2.4-21.4）。其他激素对预后影响较小。高睾丸激素预示乳腺癌复发。需要进一步的研究来确定减少睾酮的饮食或其他医疗干预是否可以减少乳腺癌的复发。
Prospective studies show that high serum levels of androgens and estrogens are associated with increased incidence of postmenopausal breast cancer. The aim of the present analysis was to study the prognostic value of serum testosterone, estradiol and related factors in postmenopausal breast cancer patients. One hundred and ten patients without clinical recurrence were included in the study. After 5.5 years of follow-up, 31 patients developed distant metastasis (16), local relapse (4), or contralateral breast cancer (11). The risk of adverse events in relation to hormone level was examined by Cox' proportional hazard modeling, adjusting for hormone receptor status and stage at diagnosis. Body mass index and serum levels of testosterone, estradiol and glucose were significantly higher in patients who recurred than those who did not. The hazard ratios were 1.8 (95 % Cl = 0.5- 6.3) for the middle and 7.2 (95% Cl = 2.4-21.4) for the upper tertiles of baseline testosterone distribution. Other hormones had only minor influence on prognosis. High testosterone predicts breast cancer recurrence. Further studies are required to determine whether dietary or other medical intervention to reduce testosterone can reduce the recurrence of breast cancer.