Molecular liaisons between erythropoiesis and iron metabolism
Molecular liaisons between erythropoiesis and iron metabolism
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DOI：
10.1182/blood-2014-05-516252
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发表时间：
2014-07-24
期刊：
影响因子：
20.3
通讯作者：
Nemeth, Elizabeta
中科院分区：
文献类型：
--
作者：
Kautz, Leon;Nemeth, Elizabeta
尽管血浆中的大多数循环铁用于红细胞生成，但红细胞生成需求调节铁供应的机制（“红细胞调节因子”）在很大程度上仍然未知。铁的吸收、血浆铁浓度和组织铁的分布受到肝脏产生的激素肝磷脂的严格控制。在过去的十年中，在阐明铁和炎症对hepcidin的调节方面取得了很大进展。本文就生理性和病理性促红细胞生成中hepcidin抑制的机制和介质作一综述。
Although most circulating iron in blood plasma is destined for erythropoiesis, the mechanisms by which erythropoietic demand modulates the iron supply ("erythroid regulators") remain largely unknown. Iron absorption, plasma iron concentrations, and tissue iron distribution are tightly controlled by the liver-produced hormone hepcidin. During the last decade, much progress has been made in elucidating hepcidin regulation by iron and inflammation. This review discusses the less understood mechanisms and mediators of hepcidin suppression in physiologically and pathologically stimulated erythropoiesis.