Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis.
Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis.
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DOI：
10.1161/hypertensionaha.114.03618
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Lakatta EG
中科院分区：
文献类型：
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作者：
Wang M;Kim SH;Monticone RE;Lakatta EG
MMP活化在动脉壁中的弹性蛋白生成（产生）和弹性蛋白溶解（降解）中起因果作用（图;表）。弹性蛋白纤维被活化的MMP-2/-9有效消化。18 MMP活化抑制剂PD 166793显著减弱弹性蛋白纤维降解。3此外，MMP激活触发ERK 1/2的磷酸化，其在体外延缓VSMC中弹性蛋白原的产生和在体内延缓大鼠主动脉中的弹性生成。13，45这些发现表明，ERK 1/2磷酸化参与的增殖与VSMC中的弹性细胞生成相关。
MMP activation plays a causal role in the elastogenesis (production) and elastolysis (degradation) in the arterial wall (Figure; Table). Elastin fibers are effectively digested by activated MMP-2/-9. 18 An MMP activation inhibitor PD166793 markedly blunts elastin fiber degradation. 3 In addition, MMP activation triggers phosphorylation of ERK1/2, which retards tropoelastin production in VSMCs in vitro and elastogenesis in the rat aorta in vivo. 13, 45 These findings suggest that proliferation in which phosphorylation of ERK1/2 is involved is coupled to the elastogenesis in VSMCs.