Effect of nimodipine (Bay e 9736) on postischaemic cerebrovascular reactivity, as revealed by measuring regional cerebral blood flow (rCBF)
Effect of nimodipine (Bay e 9736) on postischaemic cerebrovascular reactivity, as revealed by measuring regional cerebral blood flow (rCBF)
复制标题
通过测量局部脑血流量 (rCBF) 揭示尼莫地平 (Bay e 9736) 对缺血后脑血管反应性的影响
DOI：
10.1007/bf01728883
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发表时间：
2005
影响因子：
2.4
通讯作者：
H. J. Gelmers
中科院分区：
文献类型：
--
作者：
H. J. Gelmers
在静脉注射单剂量尼莫地平（Bay e 9736）之前和之后，使用氙-133颈动脉内注射技术测量10例急性缺血性卒中患者的局部脑血流量（rCBF），涉及大脑皮层。所有患者应用尼莫地平后，观察到半球血流量呈剂量依赖性增加。在区域模式中，9例患者尼莫地平治疗后，卒中区域显示出与半球血流变化相对相似的血流变化。在这些患者中，有3例的增加达到了这样一个水平，即存在逆窃血现象。未观察到脑内盗血现象。作为一种副作用，在一名患者中观察到血压和窦性心动过缓的轻度下降，持续时间较短。
Regional cerebral blood flow (rCBF) was measured, using the xenon-133 intracarotid injection technique in 10 patients with an acute ischaemic stroke, involving the cerebral cortex, before and after intravenous injection of a single dose of nimodipine (Bay e 9736). After nimodipine application in all patients a dose dependent increase of hemispheric blood flow was observed. In the regional pattern the stroke area showed, after nimodipine in 9 patients relatively similar changes in blood flow as the hemispheric flow did. In three of these patients the increase reached such a level, that the presence was concluded of an inverse steal phenomenon. The intracerebral steal phenomenon was not observed. As a side effect in one patient a mild fall in blood pressure and sinusbradycardia was observed, of short duration.