How the Disruption of Mitochondrial Redox Signalling Contributes to Ageing.
How the Disruption of Mitochondrial Redox Signalling Contributes to Ageing.
复制标题
线粒体氧化还原信号的破坏如何导致衰老。
DOI：
10.3390/antiox12040831
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发表时间：
2023-03-29
期刊：
影响因子：
7
通讯作者：
Sanz, Alberto
中科院分区：
文献类型：
--
作者：
Castejon-Vega, Beatriz;Cordero, Mario D. D.;Sanz, Alberto
过去，线粒体活性氧（mtROS）被认为是细胞代谢的副产物。由于线粒体ROS能够引起氧化损伤，它们被认为是衰老和年龄相关疾病的主要驱动因素。今天，我们知道线粒体ROS是维持细胞内稳态的细胞信使。作为细胞信使，它们在特定时间在特定位置产生，ROS信号的强度和持续时间决定了线粒体氧化还原信号的下游效应。我们还不知道mtROS重要的所有过程，但我们已经了解到它们在影响细胞分化，增殖和存活的决定中至关重要。除了由于其氧化细胞成分的能力而造成损害之外，当氧化还原信号转导失调时，mtROS还有助于退行性疾病的发作。在这里，我们回顾了最好的特点，线粒体ROS参与的信号通路和这些病理过程中，他们参与。我们专注于线粒体ROS信号是如何在衰老过程中改变，并讨论是否没有信号能力的受损线粒体的积累是衰老的原因或后果。
In the past, mitochondrial reactive oxygen species (mtROS) were considered a byproduct of cellular metabolism. Due to the capacity of mtROS to cause oxidative damage, they were proposed as the main drivers of ageing and age-related diseases. Today, we know that mtROS are cellular messengers instrumental in maintaining cellular homeostasis. As cellular messengers, they are produced in specific places at specific times, and the intensity and duration of the ROS signal determine the downstream effects of mitochondrial redox signalling. We do not know yet all the processes for which mtROS are important, but we have learnt that they are essential in decisions that affect cellular differentiation, proliferation and survival. On top of causing damage due to their capacity to oxidize cellular components, mtROS contribute to the onset of degenerative diseases when redox signalling becomes dysregulated. Here, we review the best-characterized signalling pathways in which mtROS participate and those pathological processes in which they are involved. We focus on how mtROS signalling is altered during ageing and discuss whether the accumulation of damaged mitochondria without signalling capacity is a cause or a consequence of ageing.
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DOI：
10.3390/antiox10050731
发表时间：
2021-05-06
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
de Cubas L;Pak VV;Belousov VV;Ayté J;Hidalgo E
通讯作者：
Hidalgo E
影响因子：
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作者：
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通讯作者：
Murphy MP
DOI：
10.15252/embj.201592862
发表时间：
2016-04-01
期刊：
The EMBO journal
影响因子：
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作者：
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通讯作者：
Passos JF
影响因子：
9.2
作者：
Copeland, Jeffrey M.;Cho, Jaehyoung;Walker, David W.
通讯作者：
Walker, David W.
影响因子：
64.8
作者：
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通讯作者：
Murphy, Michael P.