Effect of eicosanoid inhibition on the development of pulmonary edema after acute lung injury.
Effect of eicosanoid inhibition on the development of pulmonary edema after acute lung injury.
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类二十烷酸抑制对急性肺损伤后肺水肿发展的影响。
DOI：
10.1152/jappl.1996.80.3.915
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Sandiford,P
中科院分区：
文献类型：
--
作者：
Schuster,DP;Stephenson,AH;Holmberg,S;Sandiford,P
在急性肺损伤的实验模型中，环氧合酶抑制剂改善氧合，可能是通过引起血流从水肿的肺区域重新分布。这种对灌注模式的影响也可以减少肺泡水肿的形成。另一方面，环氧化酶抑制后肺动脉压通常会增加，这种作用可能会加剧水肿积聚。因此，我们检验了以下假设：在由油酸引起的急性肺损伤后的24- 28-h观察期间，在用甲氨蝶呤（n = 6）或血栓烷受体阻断剂ONO-3708（n = 5）治疗的动物组中，犬中肺水肿的总累积将小于仅用油酸治疗的动物组（安慰剂，n = 6）。肺水浓度（LWC），肺灌注的区域模式，和蛋白渗透性与正电子发射断层扫描的核医学成像技术进行了测量。24-28小时后，ONO-3708组的LWC显著低于（P < 0.05）甲氨蝶呤组（与安慰剂组相比，观察到类似的趋势，P = 0.12）。24-28 h后，Meclutamate组的肺动脉压最高。无论哪一组，LWC变化的唯一显著相关性是24- 28小时内肺动脉压积分。这些数据表明，血栓素抑制将减少急性肺损伤的水肿积累，但这种效果取决于尽可能减少其他原因引起的肺动脉高压的同时发展。
In experimental models of acute lung injury, cyclooxygenase inhibition improves oxygenation, presumably by causing a redistribution of blood flow away from edematous lung regions. This effect on perfusion pattern could also reduce alveolar edema formation. On the other hand, pulmonary pressures usually increase after cyclooxygenase inhibition, an effect that could exacerbate edema accumulation. Therefore we tested the following hypothesis: the total accumulation of pulmonary edema in dogs during a 24- to 28-h period of observation after acute lung injury caused by oleic acid will be less in a group of animals treated with meclofenamate (n = 6) or with the thromboxane-receptor blocker ONO-3708 (n = 5) than in a group of animals treated with oleic acid alone (placebo, n = 6). Lung water concentrations (LWC), the regional pattern of pulmonary perfusion, and protein permeability were measured with the nuclear medicine imaging technique of positron emission tomography. After 24-28 h, LWC was significantly less (P < 0.05) in the ONO-3708 group than in the meclofenamate group (a similar trend was seen compared with the placebo group, P = 0.12). After 24-28 h, pulmonary arterial pressures were highest in the meclofenamate group. Regardless of group, the only significant correlation with the change in LWC was with the integral of pulmonary pressures over the 24- to 28-h period. The data suggest that thromboxane inhibition will reduce edema accumulation in acute lung injury but that this effect depends on reducing as much as possible the simultaneous development of pulmonary hypertension from other causes.
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制备用于医学研究的短半衰期放射性气体。
影响因子：
3.4
作者：
M. Welch;M. Ter
通讯作者：
M. Ter
油酸诱导的急性肺损伤的类二十烷酸平衡和灌注再分配。
DOI：
10.1152/jappl.1992.73.5.2126
发表时间：
1992
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Stephenson,AH;Lonigro,AJ;Holmberg,SW;Schuster,DP
通讯作者：
Schuster,DP
改善急性呼吸窘迫综合征 (ARDS) 患者的生存率：1983???1993
DOI：
10.1097/00132586-199510000-00011
发表时间：
1995
期刊：
Survey of Anesthesiology
影响因子：
--
作者：
J. Milberg;D. Davis;K. Steinberg;L. Hudson
通讯作者：
L. Hudson
血栓烷不会介导佛波酯引起的狗急性肺损伤的肺动脉高压。
DOI：
10.1152/jappl.1990.69.1.345
发表时间：
1990
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Stephenson,AH;Sprague,RS;Dahms,TE;Lonigro,AJ
通讯作者：
Lonigro,AJ
通过正电子发射断层扫描测量局部肺损伤或肺泡缺氧对肺血流量和肺水的影响。
DOI：
10.1164/arrd.1986.133.6.1037
发表时间：
1986
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Schuster,DP;Marklin,GF
通讯作者：
Marklin,GF