Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes
Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes
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DOI：
10.1016/j.bmcl.2013.08.050
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发表时间：
2013-10-15
影响因子：
2.7
通讯作者：
Vu, Bich
中科院分区：
文献类型：
--
作者：
Freskos, John N.;Asmelash, Bethel;Vu, Bich
我们描述了合成，MMP-2和9的效力，并在体外评价一系列的α-砜羟肟酸MMP抑制剂共轭的一系列染料与不同的吸收/发射层最大的，可用于可视化肿瘤。(C)2013爱思唯尔有限公司保留所有权利。
We describe the synthesis, MMP-2 and 9 potency, and in vitro evaluation of a series of alpha-sulfone hydroxmate MMP inhibitors conjugated to a series of dyes with different absorption/emission lamina maxima's that can be used to visualize tumors. (C) 2013 Elsevier Ltd. All rights reserved.