HUMAN CORPUS-LUTEUM SECRETION OF RELAXIN, OXYTOCIN, AND PROGESTERONE
HUMAN CORPUS-LUTEUM SECRETION OF RELAXIN, OXYTOCIN, AND PROGESTERONE
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DOI：
10.1210/jcem-68-3-627
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发表时间：
1989-03-01
影响因子：
5.8
通讯作者：
DAWOOD, MY
中科院分区：
文献类型：
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作者：
KHANDAWOOD, FS;GOLDSMITH, LT;DAWOOD, MY
为了确定人黄体是否是松弛素和催产素的来源，我们测量了从有或没有黄体的卵巢静脉获得的血浆中这些肽的浓度，并将其与外周血浆水平进行比较。外周血和卵巢静脉血样本取自 34 名非孕妇，其中 13 名处于黄体期，21 名处于卵泡期，以及一名 6 周孕妇。血浆松弛素、催产素和黄体酮浓度通过敏感且特异的 RIA 测定。在未排出黄体的外周或卵巢静脉血浆中未检测到血浆松弛素水平（<0.16μg/L）。排出带有黄体的卵巢的血浆中的平均松弛素浓度为0.41±。 0.09(.+-.SE).mu.g/L。有黄体的卵巢引流血浆中的催产素水平 (6.70 .+-. 1.86 pmol/L) 也显着高于无黄体的卵巢引流血浆 (1.58 .+-. 0.09 pmol/L; P < 0.01) 或外周血浆 (1.58 .+-. 0.09 pmol/L; P < 0.01)。 0.025）。与来自对侧卵巢静脉的血浆 (40.3 +-. 16.5 nmol/L P < 0.005) 和外周血浆 (30.2 +-. 5.7 nmol/L; P < 0.005）在黄体期。在怀孕 6 周的女性中，通过黄体排出卵巢的血浆中含有 1.9 μg 松弛素/L，但只有 0.49 pmol/L 催产素；后者与不含黄体的卵巢静脉血浆中的浓度相似。这些发现表明，人类黄体分泌松弛素、催产素和黄体酮。卵巢催产素和松弛素均可作为黄体功能的旁分泌或自分泌调节剂。
To determine whether the human corpus luteum is a source of relaxin and oxytocin, we measured the concentrations of these peptides in plasma obtained from the ovarian veins of ovaries with and without a corpus luteum and compared these to peripheral plasma levels. Peripheral and ovarian venous blood samples were obtained from 34 nonpregnant women, 13 during the luteal phase and 21 during the follicular phase of their cycles, and from a 6-week pregnant woman. Plasma relaxin, oxytocin, and progesterone concentrations were determined by sensitive and specific RIAs. Plasma relaxin levels were not detectable (< 0.16 .mu.g/L) in peripheral or ovarian venous plasma not draining a corpus luteum. The mean relaxin concentration in plasma draining an ovary with a corpus luteum was 0.41 .+-. 0.09 (.+-. SE) .mu.g/L. Oxytocin levels also were significantly higher in plasma draining an ovary with a corpus luteum (6.70 .+-. 1.86 pmol/L) than in that draining the ovary with no corpus luteum (1.58 .+-. 0.09 pmol/L; P < 0.01) or in peripheral plasma (1.58 .+-. 0.09 pmol/L; P < 0.025). The mean progesterone concentration also was highest in plasma draining an ovary with a corpus luteum (210.2 .+-. 50.5 nmol/L) compared with those in plasma from the contralateral ovarian vein (40.3 .+-. 16.5 nmol/L P < 0.005) and peripheral plasma (30.2 .+-. 5.7 nmol/L; P < 0.005) during the luteal phase. In a woman who was 6 weeks pregnant, plasma draining the ovary with a corpus luteum has 1.9 .mu.g relaxin/L, but only 0.49 pmol/L oxytocin; the latter was similar to concentrations in noncorpus luteum-bearing ovarian venous plasma. These findings indicate that the human corpus luteum secretes relaxin, oxytocin, and progesterone. Both ovarian oxytocin and relaxin may function as paracrine or autocrine modulators of luteal function.