Pulmonary Cryptococcosis: comparison of Cryptococcal antigen detection and radiography in Immunocompetent and Immunocompromised patients
Pulmonary Cryptococcosis: comparison of Cryptococcal antigen detection and radiography in Immunocompetent and Immunocompromised patients
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DOI：
10.1186/s12879-020-4818-1
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发表时间：
2020-01-30
影响因子：
3.7
通讯作者：
Deng, Huojin
中科院分区：
文献类型：
--
作者：
Min, Jingqi;Huang, Kunlun;Deng, Huojin
背景我们比较了免疫功能正常和免疫功能低下的肺隐球菌病患者的隐球菌抗原检测和影像学表现。我们的研究的目的是确定患者的免疫状态和X线摄影是否影响隐球菌抗原的检测。方法根据是否服用免疫抑制剂，78例成人肺隐球菌病患者分为两组：免疫功能正常组和免疫功能低下组。根据CrAg的检测结果将各组分为CrAg+组和CrAg-组。然后，临床记录，实验室检查和计算机断层扫描结果进行了收集和analyzed.ResultsNo差异，发现在基线特征，临床症状，实验室检查。通过比较两组CrAg检测结果发现，免疫功能正常组CrAg+例数多于免疫功能低下组。在免疫活性组中，CrAg+组以弥漫性病变多见，CrAg-组以局限性病变多见。血清CrAg可作为免疫功能正常但肺部广泛受累的肺隐球菌病的诊断指标。
BackgroundWe compared the cryptococcal antigen detection and imaging findings between immunocompetent and immunocompromised patients in whom pulmonary cryptococcosis had been diagnosed. The aim of our study was to determine whether the patient's immune status and radiography affect the detection of cryptococcal antigen.MethodsAccording to whether they took immunosuppressive drugs or not, seventy and eight adult patients with pulmonary cryptococcosis were divided into two groups: the immunocompetent group and the immunocompromised group. According to the detection of CrAg, each group was divided into the CrAg+ group and the CrAg- group. Then, clinical records, laboratory examinations and computed tomography findings were collected and analyzed.ResultsNo difference was found in baseline characteristics, clinical symptoms, and laboratory investigations. By comparing CrAg detection in these two groups, it was found that the number of CrAg+ cases in the immunocompetent group was more than that in the immunocompromised group. And in the immunocompetent group, diffuse lesions were more common in CrAg+ group and limited lesions were more frequently observed in CrAg- group.ConclusionsThe patient's immune status and radiography would affect the detection of cryptococcal antigen. And serum CrAg could be a useful tool for the diagnosis of pulmonary cryptococcosis in immunocompetent patients with extensive lung involvement.