Cumulative Impact of Chaperone-Mediated Folding on Genome Evolution
Cumulative Impact of Chaperone-Mediated Folding on Genome Evolution
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DOI：
10.1021/bi3013643
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发表时间：
2012-12-18
期刊：
影响因子：
2.9
通讯作者：
Dagan, Tal
中科院分区：
文献类型：
--
作者：
Bogumil, David;Dagan, Tal
分子伴侣支持蛋白质折叠和解折叠以及蛋白质复合物的组装和易位。伴侣已被认为是生物体基因型和表型之间的重要中介，以及在诱导高突变负荷的环境条件下细胞健康的重要维持者。在这里，我们回顾了最近的研究，这些研究表明伴侣提供的折叠辅助在基因组序列中很明显，这表明伴侣介导的折叠是蛋白质进化过程中的一个影响因素。蛋白质与伴侣的相互作用确保了正确的折叠和功能，但对这种帮助的强制性依赖的适应可能是不可逆转的，代表了进化陷阱。对伴侣的需求和蛋白质表达水平之间的相关性表明底物伴侣相互作用的进化受到细胞内所需底物丰度的限制。越来越多的证据表明，伴侣蛋白的效用取决于其一方面有助于减轻蛋白质错误折叠和聚集体形成的风险，另一方面有助于减缓蛋白质成熟速度和伴侣蛋白合成的能量成本之间的微妙平衡。
Molecular chaperones support protein folding and unfolding along with assembly and translocation of protein complexes. Chaperones have been recognized as important mediators between an organismal genotype and phenotype as well as important maintainers of cellular fitness under environmental conditions that induce high mutational loads. Here we review recent studies revealing that the folding assistance supplied by chaperones is evident in genomic sequences implicating chaperone-mediated folding as an influential factor during protein evolution. Interaction of protein with chaperones ensures a proper folding and function, yet an adaptation to obligatory dependence on such assistance may be irreversible, representing an evolutionary trap. A correlation between the requirement for a chaperone and protein expression level indicates that the evolution of substrate-chaperone interaction is bounded by the required substrate abundance within the cell. Accumulating evidence suggets that the utility of chaperones is governed by a delicate balance between their help in mitigating the risks of protein misfolding and aggregate formation on one hand and the slower rate of protein maturation and the energetic cost of chaperone synthesis on the other.