Basic Quantitative Assessment of Visual Performance in Patients with Very Low Vision
Basic Quantitative Assessment of Visual Performance in Patients with Very Low Vision
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DOI：
10.1167/iovs.09-3512
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发表时间：
2010-02-01
影响因子：
4.4
通讯作者：
Wilke, Robert
中科院分区：
文献类型：
--
作者：
Bach, Michael;Wilke, Michaela;Wilke, Robert
目的.开发视觉假体的各种方法正在被追求：视网膜下，视网膜上，通过视神经，或通过视觉皮层。本报告提出了一种方法，比较它们在真正改善视觉功能方面的疗效，从无光感（NLP）开始。测试组系（一个计算机程序，光和运动的基本评估[BaLM]）是在四个基本视觉维度上开发的：（1）光感知（有光/无光），具有非结构化大视野刺激;（2）时间分辨率，具有单闪光与双闪光区分;（3）光的定位，其中楔形从中心延伸到四个可能的方向;以及（4）运动，其中粗略图案在四个方向中的一个方向上移动。两个或四个选择，被迫选择的范例。参与者的回答是自定进度的，并以一个简单的方式进行。对51例73眼低视力患者进行了BaLM的可行性试验。光和时间测试模块区分NLP和光感知（LP）。本地化和运动模块没有表现出显着的响应NLP，但区分LP和手部运动（HM）。所有四个模块都达到了高于HM的敏锐度类别的上限。BaLM结果在极低视力类别NLP、LP和HM之间存在系统性差异。光和时间产生了类似的结果，定位和运动也是如此;尽管如此，对于评估具有不同时间特征的视觉假体，它们并不是多余的。结果表明，这个简单的测试电池提供了从NLP到HM的极低视力范围内的视觉功能的定量评估。（Invest Ophthalmol维斯科学。2010; 51：1255-1260）DOI：10.1167/iovs.093512
PURPOSE. A variety of approaches to developing visual prostheses are being pursued: subretinal, epiretinal, via the optic nerve, or via the visual cortex. This report presents a method of comparing their efficacy at genuinely improving visual function, starting at no light perception (NLP).METHODS. A test battery (a computer program, Basic Assessment of Light and Motion [BaLM]) was developed in four basic visual dimensions: (1) light perception (light/no light), with an unstructured large-field stimulus; (2) temporal resolution, with single versus double flash discrimination; (3) localization of light, where a wedge extends from the center into four possible directions; and (4) motion, with a coarse pattern moving in one of four directions. Two- or four-alternative, forced-choice paradigms were used. The participants' responses were self-paced and delivered with a keypad.RESULTS. The feasibility of the BaLM was tested in 73 eyes of 51 patients with low vision. The light and time test modules discriminated between NLP and light perception (LP). The localization and motion modules showed no significant response for NLP but discriminated between LP and hand movement (HM). All four modules reached their ceilings in the acuity categories higher than HM.CONCLUSIONS. BaLM results systematically differed between the very-low-acuity categories NLP, LP, and HM. Light and time yielded similar results, as did localization and motion; still, for assessing the visual prostheses with differing temporal characteristics, they are not redundant. The results suggest that this simple test battery provides a quantitative assessment of visual function in the very-low-vision range from NLP to HM. (Invest Ophthalmol Vis Sci. 2010; 51: 1255-1260) DOI: 10.1167/iovs.093512