Effect of high-intensity intermittent swimming on postexercise insulin sensitivity in rat epitrochlearis muscle
Effect of high-intensity intermittent swimming on postexercise insulin sensitivity in rat epitrochlearis muscle
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DOI：
10.1016/j.metabol.2008.01.014
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发表时间：
2008-06-01
影响因子：
9.8
通讯作者：
Kawanaka, Kentaro
中科院分区：
文献类型：
--
作者：
Koshinaka, Keiichi;Sano, Akiko;Kawanaka, Kentaro
长时间有氧运动可增强肌肉葡萄糖摄取对胰岛素的敏感性，这可能是通过激活5 '-腺苷一磷酸激活蛋白激酶（AMPK）介导的。本研究的目的是检查高强度短期运动是否导致AMPK激活的显著增加，与低强度长时间有氧运动相比，在增强肌肉胰岛素敏感性方面更有效。本研究测定了大鼠上滑车肌在高强度间歇性游泳（HIS）和低强度连续性游泳（LIS）运动后的胰岛素敏感性。在HIS期间，大鼠经历了8次20秒的游泳，体重等于体重的18%。LIS大鼠无负荷游泳3小时。高强度间歇性游泳增加（P
A bout of prolonged aerobic exercise can enhance the sensitivity of muscle glucose uptake to insulin, and this may be mediated by activation of 5'-adenosine monophosphate-activated protein kinase (AMPK). The aim of this study was to examine whether high-intensity short-term exercise resulting in a significantly greater increase in the activation of AMPK is more effective in enhancing muscle insulin sensitivity compared with low-intensity prolonged aerobic exercise. We measured insulin sensitivity after high-intensity intermittent swimming (HIS) or low-intensity continuous swimming (LIS) exercise in rat epitrochlearis muscle. During HIS, the rats underwent eight 20-second bouts of swimming with a weight equal to 18% of body weight. The LIS rats swam with no load for 3 hours. High-intensity intermittent swimming increased (P