MarginProbe® : intraoperative margin assessment during breast conserving surgery by using radiofrequency spectroscopy
MarginProbe® : intraoperative margin assessment during breast conserving surgery by using radiofrequency spectroscopy
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DOI：
10.1586/erd.13.5
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发表时间：
2013-05-01
影响因子：
3.1
通讯作者：
Thill, Marc
中科院分区：
文献类型：
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作者：
Thill, Marc
在保乳手术中，肿瘤应该在边缘干净的情况下切除，周围有一圈健康组织。在初次手术中未能获得干净的边缘导致再次切除手术。据报道，浸润性癌和导管原位癌（DCIS）的再切除率为11-46%。再次切除可能会产生负面后果，如术后感染增加，对美容的负面影响，患者焦虑和医疗费用增加。因此，浸润性导管内（DCIS）乳腺组织的手术切缘是一个激烈讨论的主题。术中评估有不同的选择，但总的来说，它们都不令人满意。冰冻切片边缘检查是可能的，但耗时，并限于评估浸润性癌。在DCIS的情况下，没有术中边缘评估的程序。因此，需要一种有效的术中手术切缘评估的解决方案。为此，设计了一种创新的、实时的、术中边缘评估装置（MarginProbe（R），Dune Medical Devices，凯撒利亚，以色列），并且最近发表的临床数据报告了超过50%的再切除减少。
In breast conserving surgery, the tumor should be removed with a clean margin, a rim of healthy tissue surrounding. Failure to achieve clean margins in the initial surgery results in a re-excision procedure. Re-excision rates are reported as being 11-46% for invasive carcinoma and ductal carcinoma in situ (DCIS). Re-excisions can have negative consequences such as increased postoperative infections, negative impact on cosmesis, patient anxiety and increased medical costs. Therefore, the surgical margin of invasive and intraductal (DCIS) breast tissue is a subject of intense discussion. Different options for intraoperative assessment are available, but all in all, they are unsatisfying. Frozen section margin examination is possible but is time consuming and restricted to the assessment of invasive carcinoma. In the case of DCIS, there is no procedure for intraoperative margin assessment. Thus, a solution for efficient intraoperative surgical margin assessment is needed. For this purpose, an innovative, real-time, intraoperative margin-assessment device (MarginProbe (R), Dune Medical Devices, Caesarea, Israel) was designed, and recent published clinical data reported a reduction of re-excisions by more than 50%.