A QUANTITATIVE STUDY OF LETHAL AND TERATOGENIC EFFECTS OF HYPOXIA ON 3-DAY CHICK EMBRYO
A QUANTITATIVE STUDY OF LETHAL AND TERATOGENIC EFFECTS OF HYPOXIA ON 3-DAY CHICK EMBRYO
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DOI：
10.1002/aja.1001090104
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发表时间：
1961-01-01
影响因子：
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通讯作者：
GRABOWSKI, C
中科院分区：
文献类型：
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作者：
GRABOWSKI, C
将2000多个三天的小鸡胚胎暴露在常压下含氧量为0至21%的大气中3-24小时。记录死亡率、发育不良发生率以及体型和体重测量值。氧水平与暴露时间、死亡和异常发育之间存在规律性的定量关系。除非暴露在严重的条件下，否则胚胎体重不会受到影响。然而，即使胚胎年龄保持不变，不同的O2水平和暴露时间组合也会引起不同性质的异常。这表明缺氧对发育器官的作用模式不止一种。
Over 2000 three-day chick embryos were exposed for 3-24 hour periods to atmospheres, at normal pressures, containing from 0 to 21% oxygen. Death rates, incidence of maldevelopment, and measurements of body size and weight were recorded. Regular quantitative relationships were observed between O2 level and duration of exposure on one hand, and death and abnormal development on the other. Embryo weight was not affected except after exposure to severe conditions. However, even though embryo age was kept constant, different combinations of O2 levels and exposure times induced qualitatively different kinds of anomalies. This indicates that there is more than one mode of action of hypoxia on developing organs.