Human muscle production in vitro from pluripotent stem cells: Basic and clinical applications.
Human muscle production in vitro from pluripotent stem cells: Basic and clinical applications.
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DOI：
10.1016/j.semcdb.2021.04.017
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发表时间：
2021-11
影响因子：
7.3
通讯作者：
Pourquié O
中科院分区：
文献类型：
--
作者：
Yan L;Rodríguez-delaRosa A;Pourquié O
人类多能干细胞（PSC）具有自我更新和分化成多种细胞类型的能力，作为研究工具提供了巨大的治疗潜力和宝贵的灵活性。近年来，在指导人PSC肌源性分化方面取得了显著进展。受我们体内肌发生知识的启发，分化策略为研究人类肌肉发育和肌肉疾病建模提供了重要平台，也为治疗肌营养不良症的细胞疗法提供了有前途的细胞来源。在这篇综述中，我们总结了骨骼肌生成从人类PSC，包括转基因为基础的和转基因的分化方案，并通过生物工程方法的3D肌肉组织生产的现状。我们还强调了它们的基础和临床应用，这有助于人类肌肉生物学的研究，并为肌肉疾病治疗带来新的希望。
Human pluripotent stem cells (PSCs), which have the capacity to self-renew and differentiate into multiple cell types, offer tremendous therapeutic potential and invaluable flexibility as research tools. Recently, remarkable progress has been made in directing myogenic differentiation of human PSCs. The differentiation strategies, which were inspired by our knowledge of myogenesis in vivo, have provided an important platform for the study of human muscle development and modelling of muscular diseases, as well as a promising source of cells for cell therapy to treat muscular dystrophies. In this review, we summarize the current state of skeletal muscle generation from human PSCs, including transgene-based and transgene-free differentiation protocols, and 3D muscle tissue production through bioengineering approaches. We also highlight their basic and clinical applications, which facilitate the study of human muscle biology and deliver new hope for muscular disease treatment.
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影响因子：
11.1
作者：
Cossu G;Previtali SC;Napolitano S;Cicalese MP;Tedesco FS;Nicastro F;Noviello M;Roostalu U;Natali Sora MG;Scarlato M;De Pellegrin M;Godi C;Giuliani S;Ciotti F;Tonlorenzi R;Lorenzetti I;Rivellini C;Benedetti S;Gatti R;Marktel S;Mazzi B;Tettamanti A;Ragazzi M;Imro MA;Marano G;Ambrosi A;Fiori R;Sormani MP;Bonini C;Venturini M;Politi LS;Torrente Y;Ciceri F
通讯作者：
Ciceri F
影响因子：
6
作者：
Abujarour, Ramzey;Bennett, Monica;Flynn, Peter
通讯作者：
Flynn, Peter
影响因子：
7.7
作者：
Choi, In Young;Lim, Hotae;Lee, Gabsang
通讯作者：
Lee, Gabsang
影响因子：
4.6
作者：
Chal, Jerome;Al Tanoury, Ziad;Pourquie, Olivier
通讯作者：
Pourquie, Olivier
影响因子：
5.2
作者：
Arpke, Robert W.;Darabi, Radbod;Kyba, Michael
通讯作者：
Kyba, Michael