STUDIES OF THE PUTATIVE TRANSFORMING PROTEIN OF THE TYPE-I HUMAN T-CELL LEUKEMIA-VIRUS
STUDIES OF THE PUTATIVE TRANSFORMING PROTEIN OF THE TYPE-I HUMAN T-CELL LEUKEMIA-VIRUS
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DOI：
10.1126/science.2990027
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
CHEN, ISY
中科院分区：
文献类型：
--
作者：
SLAMON, DJ;PRESS, MF;CHEN, ISY
I型人类T细胞白血病病毒（HTLV-I）的推定转化蛋白是由X区域编码的40千道尔顿蛋白，称为p40 xI。亚细胞分离技术和免疫细胞化学分析的基础上，它表明，p40 xI是一种核蛋白，具有相对较短的半衰期（120分钟）。它在体外被病毒感染和转化的人T细胞系中以相当大的量从头合成，并且在细胞外病毒中不以可检测的量包装。
The putative transforming protein of the type I human T-cell leukemia virus (HTLV-I) is a 40-kilodalton protein encoded by the X region and is termed p40xI. On the basis of both subcellular fractionation techniques and immunocytochemical analysis, it was shown that p40xI is a nuclear protein with a relatively short half-life (120 min). It is synthesized de novo in considerable quantities in a human T-cell line infected with and transformed by the virus in vitro and it is not packaged in detectable amounts in the extracellular virus.