Correlation Between the Myopic Retinal Deformation and Corneal Biomechanical Characteristics Measured With the Corvis ST Tonometry
Correlation Between the Myopic Retinal Deformation and Corneal Biomechanical Characteristics Measured With the Corvis ST Tonometry
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DOI：
10.1167/tvst.8.4.26
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发表时间：
2019-07-01
影响因子：
3
通讯作者：
Kiuchi, Yoshiaki
中科院分区：
文献类型：
--
作者：
Asano, Shotaro;Asaoka, Ryo;Kiuchi, Yoshiaki
目的：我们之前报道过，近视引起的视网膜变形由视乳头周围视网膜动脉角（PRAA）表示。在本研究中，我们研究了 PRAA 与 Corvis ST (CST) 眼压计测量的生物力学特性之间的关系。方法：纳入了接受 CST 测量的 34 名受试者的 34 只正常眼睛。 PRAA 是根据眼底照片计算的。使用二阶偏差校正 Akaike 信息准则指数进行模型选择，从年龄、眼轴、等效球面屈光不正和 10 个 CST 参数中识别出与 PRAA 相关的变量。结果：用眼轴长度（系数 = -5.66，P < 0.0001）、最大偏转幅度（mm；系数 = 130.5，P = 0.0004）和偏转幅度比来最好地描述 PRAA。 (DA比率)2mm(系数=-25.8，P=0.0032)，其中mm是最大角膜顶点移动量，DA比率2mm是顶点处和距顶点2mm处的变形幅度之间的比率。最优模型明显优于仅使用眼轴长度的模型（P = 0.0014，方差分析）。结论：与仅使用眼轴长度的模型相比，使用CST参数显着更好地描述了PRAA；具有较小 PRAA（较大近视视网膜变形）的眼睛显示出狭窄且浅的最大角膜偏转。 转化相关性：代表角膜生物力学特征的 Corvis ST 参数与近视视网膜变形相关。
Purpose: We previously reported that the retinal deformation due to myopia was represented by the peripapillary retinal arteries angle (PRAA). In this study, we investigated the relationship between the PRAA and biomechanical properties measured with Corvis ST (CST) tonometry.Methods: Thirty-four normative eyes of 34 subjects who underwent CST measurement were enrolled. The PRAA was calculated from a fundus photograph. Variables related to the PRAA were identified from age, axial length, spherical equivalent refractive error, and 10 CST parameters using model selection with the second-order bias-corrected Akaike information criterion index.Results: The PRAA was best described with axial length (coefficient = -5.66, P < 0.0001), maximum deflection amplitude (mm; coefficient = 130.5, P = 0.0004), and deflection amplitude ratio (DA ratio) 2 mm (coefficient = -25.8, P = 0.0032), where mm was the amount of the maximum corneal apex movement and DA ratio 2 mm was the ratio between the deformation amplitudes at the apex and 2 mm away from the apex. The optimal model was significantly better than the model only with axial length (P = 0.0014, analysis of variance).Conclusions: The PRAA was significantly better described with the CST parameters compared to the axial length model only; eyes with small PRAA (larger myopic retinal deformation) showed narrow and shallow maximum corneal deflection.Translational Relevance: The Corvis ST parameters, which represents corneal biomechanical characteristics, were associated with myopic retinal deformation.