Trophoblastic lesions of the placental site.
Trophoblastic lesions of the placental site.
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胎盘部位的滋养层病变。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
J. Rutgers
中科院分区：
文献类型：
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作者：
R. Baergen;J. Rutgers
绒毛滋养层与葡萄胎和绒毛膜癌一样，已被认识和研究多年。然而，滋养层包括着床部位，绒毛膜板，绒毛膜层，细胞岛和隔膜只是在最近几年才得到关注的文献。这些“绒毛外”滋养层细胞最初被称为“X”细胞，因为怀疑它们是否来源于母体或胎儿组织（70）。随后的研究确定它们起源于滋养层细胞（42），但术语X细胞今天仍被一些研究人员使用（30，4）。由于其性质和起源仍不确定，因此使用了许多其他术语，包括合胞体游走细胞（21）、胎盘部位滋养层、胎盘部位巨细胞（42）、绒毛外滋养层（25）、绒毛外细胞滋养层、非绒毛滋养层和中间滋养层（49）。光学显微镜和免疫组织化学研究已经阐明了绒毛外滋养层（48-50）的特定形态学和生物化学特征，绒毛外滋养层通常被称为“中间滋养层”。胎盘部位的“中间”或绒毛外滋养层病变包括胎盘部位肥大、胎盘部位滋养层肿瘤和最近描述的胎盘部位结节。本文将回顾这些病变的临床和病理特征，其鉴别诊断，治疗和预后因素后，讨论的起源，性质和定义的“中间”滋养细胞。
The trophoblast of the chorionic villi as well as the hydatidiform mole and choriocarcinoma have been recognized and studied for many years. However, the trophoblast comprising the implantation site, chorionic plate, chorion laeve, cell islands and septa have only in recent years received attention in the literature. These "extravillous" trophoblastic cells were originally referred to as "X" cells due to doubt regarding their derivation from either maternal or fetal tissue (70). Subsequent studies determined that they were trophoblastic in origin (42), but the term X-cell is still in use today by some researchers (30, 4). Due to continued uncertainty regarding their nature and origin, many other terms have been used including syncytial wandering cells (21), placental site trophoblast, placental site giant cells (42), extravillous trophoblast (25), extravillous cytotrophoblast, nonvillous trophoblast, and intermediate trophoblast (49). Light microscopic and immunohistochemical studies have led to elucidation of specific morphologic and biochemical features of the extravillous trophoblast (48-50) which is commonly designated as the "intermediate trophoblast". Lesions of the "intermediate" or extravillous trophoblast of the placental site include the exaggerated placental site, the placental site trophoblast tumor and the recently described placental site nodule. This article will review the clinical and pathologic features of these lesions, their differential diagnosis, treatment, and prognostic factors after discussion of the origin, nature and definition of the "intermediate" trophoblast.