Effect of a probiotic food as an adjuvant to triple therapy for eradication of Helicobacter pylori infection in children
Effect of a probiotic food as an adjuvant to triple therapy for eradication of Helicobacter pylori infection in children
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DOI：
10.1016/j.nut.2006.06.008
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发表时间：
2006-10-01
期刊：
影响因子：
4.4
通讯作者：
Boccio, Jose R.
中科院分区：
文献类型：
--
作者：
Goldman, Cinthia G.;Barrado, Domingo A.;Boccio, Jose R.
目的：目前治疗幽门螺杆菌感染的建议包括质子泵抑制剂联合两种抗生素。我们评估了一种益生菌食品作为抗生素三联疗法的佐剂在根除阿根廷布宜诺斯艾利斯儿童幽门螺杆菌感染方面的潜在活性。方法：65名经C-13-尿素呼气试验和胃镜检查证实为幽门螺杆菌阳性的儿童参与了这项研究。患者随机接受1周三联疗法加益生菌食品(治疗组)或牛奶安慰剂(对照组)，持续3个月。益生菌食品包括250毫升含有动物双歧杆菌和干酪乳杆菌的商业酸奶(10(7)个菌落形成单位/毫升)。结果：治疗1mo和3mo时，治疗组幽门螺杆菌根除率分别为45.5%和42.4%，对照组分别为37.5%和40.6%，两组比较差异无统计学意义。第1个月的相对危险度WERP0.87(95%可信区间0.58~1.32，P=0.345)和第3个月的相对危险度0.97(95%可信区间0.64~1.46，P=0.542)。结论：在阿根廷布宜诺斯艾利斯，我们不能证明所研究的益生菌食品对三联疗法根除儿童幽门螺杆菌感染有辅助作用。然而，我们发现。与发达国家报道的相同治疗方案相比，ER值更低，这表明应该研究细菌耐药性和替代治疗策略。(C)2006 Elsevier Inc.保留所有权利。
Objective: Current recommendations for treatment of Helicobacter pylori infection include a proton pump inhibitor in combination with two antibiotics. We evaluated the potential activity of a probiotic food as an adjuvant to antibiotic triple therapy for eradication of H. pylori infection in children from Buenos Aires, Argentina.Methods: Sixty-five children who tested positive for H. pylori, as diagnosed by C-13-urea breath test and endoscopy, were included in this study. Patients were randomized to receive 1-wk triple therapy plus probiotic food (treated group) or milk placebo (control) that was administered for 3 mo. Probiotic food consisted of 250 mL of a commercial yogurt containing Bifidobacterium animalis and Lactobacillus casei (10(7) colony-forming units/mL). Post-treatment urea breath test controls were performed 1 and 3 mo after the end of triple therapy.Results: We found no significant differences in H. pylori eradication rates (ERs) at 1 and 3 mo between the treated group (ER = 45.5% and 42.4%) and the control group (ER = 37.5% and 40.6%). Relative risks between groups werp 0.87 (95% confidence interval 0.58-1.32, P = 0.345) in the first month and 0.97 (95% confidence interval 0.64-1.46, P = 0.542) in the third month.Conclusions: We could not demonstrate an adjuvant effect of the studied probiotic food to triple therapy in the eradication of H. pylori infection in children in Buenos Aires, Argentina. However, we found. lower ERs than those reported for the same therapeutic scheme in developed countries, indicating that bacterial resistance and alternative therapeutic strategies should be studied. (C) 2006 Elsevier Inc. All rights reserved.