Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer's disease and Down syndrome.
Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer's disease and Down syndrome.
复制标题
阿尔茨海默病和唐氏综合症患者大脑中 14-3-3 γ 和 epsilon 蛋白的水平增加。
DOI：
10.1007/978-3-7091-6380-1_23
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
G. Lubec
中科院分区：
文献类型：
--
作者：
M. Fountoulakis;N. Cairns;G. Lubec
14-3-3家族由同源和异二聚体蛋白组成，代表了一种新型的“接头蛋白”，调节信号转导途径组分之间的相互作用。14-3-3同工型与激酶、磷酸酶、凋亡相关蛋白等蛋白上的磷酸丝氨酸基序相互作用。通过二维电泳在人脑中进行蛋白质定位，我们鉴定了两种同工异构体，14-3-3 γ和epsilon，并决定在老年阿尔茨海默病（AD）和唐氏综合征（DS）患者的几个大脑区域与对照大脑进行比较，确定这两种多功能蛋白。AD和DS患者部分脑区14-3-3 gamma和14-3-3 epsilon蛋白升高。这些变化可能导致AD和DS中AD的复杂病理机制，从生命的第四个十年开始不可避免地演变。紊乱的14-3-3亚型γ和epsilon可能反映了大脑中信号传导和/或凋亡的受损，因为一些激酶（蛋白激酶C、Ras、丝裂原活化激酶MEK）参与信号传导和凋亡因子，如bcl-2相关蛋白BAD和BAG-1与14-3-3基序结合。
The 14-3-3 family consists of homo- and heterodimeric proteins representing a novel type of "adaptor proteins" modulating the interaction between components of signal transduction pathways. 14-3-3 isoforms interact with phosphoserine motifs on many proteins as kinases, phosphatases, apoptosis related proteins etc. Performing protein mapping by 2D electrophoresis in human brain we identified two isoforms, 14-3-3 gamma and epsilon and decided to determine these two multifunctional proteins in several brain regions of aged patients with Alzheimer's disease (AD) and Down Syndrome (DS) with AD neuropathology in comparison with control brains. 14-3-3 gamma and 14-3-3 epsilon proteins were increased in several brain regions of AD and DS patients. These changes may contribute to the complex pathomechanisms of AD and AD in DS, evolving inevitably from the fourth decade of life. Deranged 14-3-3 isoforms gamma and epsilon may reflect impaired signaling and/or apoptosis in the brain as several kinases (protein kinase C, Ras, mitogen-activated kinase MEK) involved in signaling and apoptotic factors as bcl-2-related proteins BAD and BAG-1 are binding to 14-3-3 motifs.
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影响因子：
158.5
作者：
Hsich, G;Kinney, K;Harrington, MG
通讯作者：
Harrington, MG
影响因子：
3.3
作者：
Kumagai, A;Yakowec, PS;Dunphy, WG
通讯作者：
Dunphy, WG
影响因子：
--
作者：
J. C. Morris;R. Mohs;H. Rogers;G. Fillenbaum;A. Heyman
通讯作者：
J. C. Morris;R. Mohs;H. Rogers;G. Fillenbaum;A. Heyman
DOI：
10.1073/pnas.93.14.7063
发表时间：
1996-07-09
影响因子：
11.1
作者：
Wang, HG;Takayama, S;Reed, JC
通讯作者：
Reed, JC
影响因子：
56.9
作者：
Peng, CY;Graves, PR;PiwnicaWorms, H
通讯作者：
PiwnicaWorms, H