Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform.
Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform.
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DOI：
10.3390/vaccines3040814
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发表时间：
2015-10-06
期刊：
影响因子：
7.8
通讯作者：
Zhang L
中科院分区：
文献类型：
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作者：
Angsantikul P;Thamphiwatana S;Gao W;Zhang L
纳米颗粒在增强免疫治疗效力方面表现出独特的优势，并引起了人们对开发安全有效的疫苗制剂的日益浓厚的兴趣。最近的技术进步导致了细胞膜涂层纳米颗粒的发现和开发，它结合了细胞膜的丰富功能和合成纳米材料的工程灵活性。这种新型仿生纳米粒子激发了新颖的疫苗设计策略，具有调节抗菌免疫的强大潜力。本文将回顾利用细胞膜包被的纳米颗粒进行抗菌疫苗接种的最新进展。具体来说，将讨论两个主要的发展策略，即（i）通过细菌毒素隔离来针对毒力因子进行疫苗接种； (ii) 通过模仿细菌抗原呈递来针对病原体进行疫苗接种。
Nanoparticles have demonstrated unique advantages in enhancing immunotherapy potency and have drawn increasing interest in developing safe and effective vaccine formulations. Recent technological advancement has led to the discovery and development of cell membrane-coated nanoparticles, which combine the rich functionalities of cellular membranes and the engineering flexibility of synthetic nanomaterials. This new class of biomimetic nanoparticles has inspired novel vaccine design strategies with strong potential for modulating antibacterial immunity. This article will review recent progress on using cell membrane-coated nanoparticles for antibacterial vaccination. Specifically, two major development strategies will be discussed, namely (i) vaccination against virulence factors through bacterial toxin sequestration; and (ii) vaccination against pathogens through mimicking bacterial antigen presentation.