Methadone and buprenorphine for opioid dependence during pregnancy: a retrospective cohort study.
Methadone and buprenorphine for opioid dependence during pregnancy: a retrospective cohort study.
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DOI：
10.1097/adm.0000000000000092
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发表时间：
2015-03
影响因子：
5.5
通讯作者：
Heil SH
中科院分区：
文献类型：
--
作者：
Meyer MC;Johnston AM;Crocker AM;Heil SH
比较一组接受美沙酮与丁丙诺啡治疗的阿片类药物依赖孕妇的母亲特征、产前护理和新生儿结局。回顾性队列研究。 2000 年至 2012 年间，609 名阿片类药物依赖孕妇在同一机构接受美沙酮 (n=248) 或丁丙诺啡 (n=361) 治疗。接受丁丙诺啡治疗的母亲更有可能在怀孕前或怀孕早期开始用药，怀孕时间更长，婴儿更大。与使用美沙酮维持的母亲相比，使用丁丙诺啡的母亲所生的新生儿需要进行新生儿戒断治疗的次数明显更少，持续时间也更短。这些数据表明，在临床实践中，使用丁丙诺啡治疗妊娠期间阿片类药物依赖后的妊娠结局与美沙酮的结局一样好，而且往往更好。这些结果与随机临床试验的疗效数据一致，并进一步支持丁丙诺啡用于治疗妊娠期间阿片类药物依赖。
To compare maternal characteristics, prenatal care and newborn outcomes in a cohort of opioid-dependent pregnant women treated with methadone vs. buprenorphine. Retrospective cohort study. 609 pregnant, opioid-dependent women were treated with methadone (n=248) or buprenorphine (n=361) between 2000–2012 at a single institution. Mothers treated with buprenorphine were more likely to start medication prior to or earlier in pregnancy, had longer gestation and larger infants. Newborns of buprenorphine- vs. methadone-maintained mothers required treatment for neonatal abstinence significantly less often and for a shorter duration. These data suggest pregnancy outcomes following buprenorphine to treat opioid dependence during pregnancy in clinical practice are as good and often better than outcomes with methadone. These results are consistent with efficacy data from randomized clinical trials and further support the use of buprenorphine for the treatment of opioid-dependence during pregnancy.