Differential modulation of clock speed by the administration of intermittent versus continuous cocaine
Differential modulation of clock speed by the administration of intermittent versus continuous cocaine
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DOI：
10.1037/0735-7044.118.1.150
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发表时间：
2004-02-01
影响因子：
1.9
通讯作者：
Meck, WH
中科院分区：
文献类型：
--
作者：
Matell, MS;King, GR;Meck, WH
在大鼠中评估了精神兴奋剂敏化和耐受性在秒至分钟范围内的时间感知中所起的作用。通过每日注射间歇性（诱导致敏）或通过渗透性微型泵连续给药（诱导耐受性），持续2周给予钴（20 mg/kg/天）。在整个给药和停药期间评价间隔时间。注射可卡因会导致峰值时间立即发生成比例的10%偏移，这表明内部时钟的速度增加。这些变化随着重复给药而逐渐增大，表明刺激素诱导的时钟速度增加可以被敏化。连续给予可卡因没有产生可靠的效果。这些结果表明，致敏机制可能在药物诱导的时间感知改变中发挥相当大的作用。
The roles that psychostimulant sensitization and tolerance play in temporal perception in the seconds-to-minutes range were assessed in rats. Cocaine (20 mg/kg/day) was administered for 2 weeks either intermittently via daily injections (induces sensitization) or continuously via an osmotic minipump (induces tolerance). Interval timing was evaluated throughout administration and withdrawal. Injections of cocaine caused immediate, proportional, leftward shifts in peak times, indicating an increase in the speed of an internal clock. These shifts grew progressively larger with repeated administration, indicating that stimutant-induced increases in clock speed can be sensitized. Continuous cocaine administration produced no reliable effects. These results suggest that the mechanisms of sensitization may play a considerable role in drug-induced alterations of the perception of time.