Yeast prions [URE3] and [PSI+] are diseases
Yeast prions [URE3] and [PSI+] are diseases
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DOI：
10.1073/pnas.0504882102
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发表时间：
2005-07-26
影响因子：
11.1
通讯作者：
Wickner, RB
中科院分区：
文献类型：
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作者：
Nakayashiki, T;Kurtzman, CP;Wickner, RB
尽管对宿主来说是一种负担，但病毒、质粒和普恩病毒仍可以在自然界传播。由于在106个酵母细胞中有一个以上从头产生一个普恩蛋白，并在减数分裂过程中传播给所有后代，因此在野生菌株中没有它将意味着它对宿主有净有害影响。在70株野生酵母菌中，有11株有[PIN+]蛋白，而[URE3]和[PSI+]蛋白均缺失。在38个野生株中发现了自私的2亩DNA，在8个、14个和1个株系中分别发现了L-BC、20S和23S的自私RNA复制子。野生型菌株中没有[URE3]和[PSI+]，这表明每个Pron对其宿主都有净的有害作用。
Viruses, plasmids, and prions can spread in nature despite being a burden to their hosts. Because a prion arises de novo in more than one in 106 yeast cells and spreads to all offspring in meiosis, its absence in wild strains would imply that it has a net deleterious effect on its host. Among 70 wild Saccharomyces strains, we found the [PIN+] prion in 11 strains, but the [URE3] and [PSI+] prions were uniformly absent. In contrast, the "selfish" 2 mu DNA was in 38 wild strains and the self ish RNA replicons L-BC, 20S, and 23S were found in 8, 14, and 1 strains, respectively. The absence of [URE3] and [PSI+] in wild strains indicates that each prion has a net deleterious effect on its host.