Estimating the Burden of 2009 Pandemic Influenza A (H1N1) in the United States (April 2009-April 2010)
Estimating the Burden of 2009 Pandemic Influenza A (H1N1) in the United States (April 2009-April 2010)
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DOI：
10.1093/cid/ciq012
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发表时间：
2011-01-01
影响因子：
11.8
通讯作者：
Meltzer, Martin I.
中科院分区：
文献类型：
--
作者：
Shrestha, Sundar S.;Swerdlow, David L.;Meltzer, Martin I.
为了计算2009年甲型H1N1流感在美国的负担，我们根据疾病控制和预防中心的新发感染项目实验室确认的全美住院人数进行了推断，然后修正了漏报的情况。从2009年4月12日至2010年4月10日，我们估计美国约有6,080万例(范围：4,330万-8,930万例)，274,304例住院(195,086-402,719例)，以及12,469例死亡(8,868-18,306例)。87%的死亡发生在65岁以下的人群中，儿童和在职成年人住院和死亡的风险分别是1976-2001年季节性流感影响估计值的4至7倍和8至12倍。在我们的研究中，65岁或65岁以上的成年人的住院率和死亡率分别比季节性流感低75%和81%。这些结果证实了对PH1N1采取协调一致的公共卫生应对措施的必要性。
To calculate the burden of 2009 pandemic influenza A (pH1N1) in the United States, we extrapolated from the Centers for Disease Control and Prevention's Emerging Infections Program laboratory-confirmed hospitalizations across the entire United States, and then corrected for underreporting. From 12 April 2009 to 10 April 2010, we estimate that approximately 60.8 million cases (range: 43.3-89.3 million), 274 304 hospitalizations (195 086-402 719), and 12 469 deaths (8868-18 306) occurred in the United States due to pH1N1. Eighty-seven percent of deaths occurred in those under 65 years of age with children and working adults having risks of hospitalization and death 4 to 7 times and 8 to 12 times greater, respectively, than estimates of impact due to seasonal influenza covering the years 1976-2001. In our study, adults 65 years of age or older were found to have rates of hospitalization and death that were up to 75% and 81%, respectively, lower than seasonal influenza. These results confirm the necessity of a concerted public health response to pH1N1.