Circadian regulation of growth hormone secretion after treatment in acromegaly.
Circadian regulation of growth hormone secretion after treatment in acromegaly.
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肢端肥大症治疗后生长激素分泌的昼夜节律调节。
DOI：
10.1210/jcem-50-2-322
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
J. Bert
中科院分区：
文献类型：
--
作者：
P. Jaquet;M. Guibout;C. Jaquet;F. Grisoli;B. C. Devolx;D. Dumas;J. Bert
在8例因肢端肥大症接受经蝶窦腺瘤切除术的患者中，术后1-4年基线血浆GH水平始终低于8 ng/ml。每隔20分钟测定一次血浆GH，持续24 h，并在随访期间检查对口服葡萄糖、静脉注射TRH和口服溴隐亭的反应。2小时平均（±SD）GH值范围为1.1 ± 0.9 - 10.8 ± 4.9 ng/ml。这些平均值的统计分析允许识别两组患者。在每个组I患者（5例）中，平均24小时GH水平小于或等于2.0 ng/ml。观察到1 ~ 4个白天GH分泌高峰，其间有低分泌期。在所有5例病例中，均发现夜间GH显著升高;仅2例患者的这种升高与深度睡眠的开始相吻合。本组患者术后对动态试验的反应恢复正常。在第II组患者（3例病例）中，平均（±SD）24小时GH水平范围为46 ± 1.0至10.8 ± 4.9 ng/ml。两名患者介绍…
In eight patients who underwent transsphenoidal adenomectomy for acromegaly,baselineplasma GH levels were consistently less than 8 ng/ml during 1–4 yr postoperatively. Plasma GH was measured every 20 min for 24 h, and the responses to oral glucose, iv TRH, and oral bromocriptine were examined during the follow—up. The 2-h mean (±SD) GH value varied from 1.1 ± 0.9 to 10.8 ± 4.9 ng/ml. Statistical analysis of these mean values allowed identification of two groups of patients. In each group I patient (five cases), the mean 24-h GH level was less than or equal to 2.0 ng/ml. One to four daytime GH secretion peakswith intervening periods oflow secretory activity were observed. In all five cases, a significant nocturnal GH rise was found; this rise coincided with the onset of deep sleep in only two patients. Responses to dynamic tests returned t o normal after surgery in this group. In group II patients (three cases), the mean (±SD) 24-h GH levels varied from 46 ± 1.0 to 10.8 ± 4.9 ng/ml. Two patients presented ...