Increased free cholesterol in plasma low and very low density lipoproteins in non-insulin-dependent diabetes mellitus: its role in the inhibition of cholesteryl ester transfer.
Increased free cholesterol in plasma low and very low density lipoproteins in non-insulin-dependent diabetes mellitus: its role in the inhibition of cholesteryl ester transfer.
复制标题
非胰岛素依赖型糖尿病中血浆低密度脂蛋白和极低密度脂蛋白中游离胆固醇的增加：其在抑制胆固醇酯转移中的作用。
DOI：
10.1073/pnas.81.8.2512
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发表时间：
1984
影响因子：
11.1
通讯作者：
Fielding,PE
中科院分区：
文献类型：
--
作者：
Fielding,CJ;Reaven,GM;Liu,G;Fielding,PE
正常受试者的低密度脂蛋白和极低密度脂蛋白（VLDL和LDL）与非胰岛素依赖型糖尿病患者血浆的重组显著增加了胆固醇酯向这些脂蛋白转移的降低率，这是糖尿病血浆的特征，而糖尿病患者的VLDL和LDL降低了正常血浆中的胆固醇酯转移率。与正常人相比，糖尿病血浆中的VLDL和LDL的游离胆固醇与磷脂之比增加，与正常人不同的是，VLDL和LDL自发地将游离胆固醇转化为高密度脂蛋白。这些数据表明，在非胰岛素依赖型糖尿病中，胆固醇酯向这些脂蛋白转移的阻碍是由游离胆固醇含量增加介导的，这可能与这些患者发生动脉粥样硬化的风险增加有关。
Recombination of low and very low density lipoproteins (VLDL and LDL) from normal subjects with plasma from patients with non-insulin-dependent diabetes mellitus significantly increased the reduced rate of transfer of cholesteryl ester to these lipoproteins, which is characteristic of diabetic plasma, whereas diabetic VLDL and LDL reduced cholesteryl ester transfer rates in normal plasma. VLDL and LDL from diabetic plasma had an increased ratio of free cholesterol to phospholipid compared to normal, and unlike normal VLDL and LDL spontaneously lost free cholesterol to high density lipoprotein. These data suggest that the block to cholesteryl ester transfer to these lipoproteins in non-insulin-dependent diabetes is mediated by their increased free cholesterol content and may be related to the increased risk of these patients for developing atherosclerosis.