Characteristics of Kenyan women using HIV PrEP enrolled in a randomized trial on doxycycline postexposure prophylaxis for sexually transmitted infection prevention.
Characteristics of Kenyan women using HIV PrEP enrolled in a randomized trial on doxycycline postexposure prophylaxis for sexually transmitted infection prevention.
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DOI：
10.1186/s12905-023-02413-0
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发表时间：
2023-06-03
影响因子：
2.5
通讯作者：
Stewart, Jenell
中科院分区：
文献类型：
--
作者：
Oware, Kevin;Adiema, Lydia;Rono, Bernard;Violette, Lauren R.;McClelland, R. Scott;Donnell, Deborah;Scoville, Caitlin W.;Odoyo, Josephine;Baeten, Jared M.;Bukusi, Elizabeth;Stewart, Jenell
过去十年来，全球性传播感染发病率迅速上升，每天有100多万例可治愈的性传播感染。撒哈拉以南非洲的年轻妇女感染可治愈性传播感染和艾滋病毒的流行率和发病率都很高。使用强力霉素作为预防性传播感染的预防手段是有希望的;然而，迄今为止，临床试验仅在高收入环境中的男男性行为者（MSM）中进行。我们描述了参加第一项试验的参与者的特征，以确定多西环素暴露后预防（PEP）的有效性，以减少每日口服HIV暴露前预防（PrEP）的女性STI发病率。这是一项关于多西环素PEP与标准治疗（例如，每季度进行一次性传播感染筛查和治疗），以减少≥18岁且≤30岁的肯尼亚女性发生细菌性性传播感染（淋病奈瑟菌、沙眼衣原体和梅毒螺旋体）。所有人都接受了艾滋病毒暴露前预防（PrEP）。我们描述了参与者的基线特征、STI患病率和STI风险感知。2020年2月至2021年11月，共有449名女性入组。中位年龄为24岁（IQR 21-27），大多数从未结婚（66.1%），370名妇女（82.4%）报告有主要性伴侣，33%在入组前三个月内与新伴侣发生性关系。三分之二（67.5%，268名妇女）没有使用安全套，36.7%的人报告了交易性行为，43.2%的人怀疑他们的男性伴侣与其他女性发生性关系。略低于一半（45.9%，206名妇女）最近担心受到性传播感染。性病患病率为17.9%，其中C.沙眼占感染的大多数。性传播感染的感知风险与性传播感染的检测无关。在肯尼亚使用艾滋病毒PrEP并参加了一项多西环素暴露后预防试验的年轻顺性别妇女，可治愈性传播感染的患病率很高，是性传播感染预防干预的目标人群。
The global incidence of sexually transmitted infections (STIs) has been rapidly increasing over the past decade, with more than one million curable STIs being acquired daily. Young women in sub-Saharan Africa have a high prevalence and incidence of both curable STIs and HIV. The use of doxycycline as a prophylaxis to prevent STIs is promising; however, clinical trials, to date, have only been conducted among men who have sex with men (MSM) in high-income settings. We describe the characteristics of participants enrolled in the first trial to determine the efficacy of doxycycline post-exposure prophylaxis (PEP) to reduce STI incidence among women taking daily, oral HIV pre-exposure prophylaxis (PrEP). This is an open-label 1:1 randomized clinical trial on the efficacy of doxycycline PEP compared with standard of care (e.g., quarterly STI screening and treatment) to reduce incident bacterial STIs – Neisseria gonorrhoeae, Chlamydia trachomatis, and Treponema pallidum – among Kenyan women aged ≥18 and ≤30 years. All were also taking HIV pre-exposure prophylaxis (PrEP). We describe the baseline characteristics, STI prevalence, and STI risk perception of participants. Between February 2020 and November 2021, 449 women were enrolled. The median age was 24 years (IQR 21–27), the majority were never married (66.1%), 370 women (82.4%) reported having a primary sex partner, and 33% had sex with new partners in the three months prior to enrolment. Two-thirds (67.5%, 268 women) did not use condoms, 36.7% reported transactional sex, and 43.2% suspected their male partners of having sex with other women. Slightly less than half (45.9%, 206 women) were recently concerned about being exposed to an STI. The prevalence of STIs was 17.9%, with C. trachomatis accounting for the majority of infections. Perceived risk of STIs was not associated with the detection of an STI. Young cisgender women using HIV PrEP in Kenya and enrolled in a trial of doxycycline postexposure prophylaxis had a high prevalence of curable STIs and represent a target population for an STI prevention intervention.
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DOI：
10.1097/qai.0000000000001567
发表时间：
2018-01-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Price JT;Rosenberg NE;Vansia D;Phanga T;Bhushan NL;Maseko B;Brar SK;Hosseinipour MC;Tang JH;Bekker LG;Pettifor A
通讯作者：
Pettifor A
影响因子：
56.3
作者：
Molina, Jean-Michel;Charreau, Isabelle;Meyer, Laurence
通讯作者：
Meyer, Laurence
DOI：
10.2471/blt.08.059212
发表时间：
2009-11-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Steen, Richard;Wi, Teodora Elvira;Ndowa, Francis
通讯作者：
Ndowa, Francis
影响因子：
38.2
作者：
Unemo, Magnus;Lahra, Monica M.;Wi, Teodora
通讯作者：
Wi, Teodora
影响因子：
15.8
作者：
Torrone EA;Morrison CS;Chen PL;Kwok C;Francis SC;Hayes RJ;Looker KJ;McCormack S;McGrath N;van de Wijgert JHHM;Watson-Jones D;Low N;Gottlieb SL;STIMA Working Group
通讯作者：
STIMA Working Group