Depression, migraine with aura and migraine without aura: their familiality and interrelatedness
Depression, migraine with aura and migraine without aura: their familiality and interrelatedness
复制标题
DOI：
10.1111/j.1468-2982.2008.01808.x
复制
发表时间：
2009-08-01
期刊：
影响因子：
4.9
通讯作者：
McGuffin, P.
中科院分区：
文献类型：
--
作者：
Ball, H. A.;Samaan, Z.;McGuffin, P.
偏头痛经常与抑郁症并存。这两种疾病似乎有共同的病因，但抑郁症患者偏头痛的病因，特别是先兆的意义，却鲜有研究。根据国际头痛协会指南，大量一致抑郁的兄弟姐妹对样本[抑郁网络（DeNT）样本]被评估为有先兆偏头痛（MA）、无先兆偏头痛（MoA）、可能偏头痛或无偏头痛。兄弟姐妹偏头痛状况之间的相关性被用来评估偏头痛的家族易感性的性质。多阈值等相关模型最适合，其中不同的综合征被概念化为一个潜在维度的不同严重程度，而不是具有单独的病因。因此，MA 和 MoA 被发现是同一疾病的不同形式，其中 MA 占据责任范围的更极端。讨论了对我们理解偏头痛和抑郁症之间关系的影响。
Migraine is frequently comorbid with depression. There appear to be common aetiological factors for both disorders, but the aetiology of migraine within depressed patients, in particular the significance of aura, has been little studied. A large sample of concordantly depressed sibling pairs [the Depression-Network (DeNT) sample] was assessed as having migraine with aura (MA), migraine without aura (MoA), probable migraine or no migraine according to International Headache Society guidelines. Correlations between siblings' migraine status were used to assess the nature of familial liability to migraine. A multiple threshold isocorrelational model fit best, in which different syndromes are conceptualized as different severities of one underlying dimension rather than as having separate aetiologies. Thus, MA and MoA were found to be different forms of the same disorder, with MA occupying the more extreme end of the spectrum of liability. Implications for our understanding of the relationship between migraine and depression are discussed.