Clonal multidrug-resistant Shigella dysenteriae type 1 strains associated with epidemic and sporadic dysenteries in Eastern India
Clonal multidrug-resistant Shigella dysenteriae type 1 strains associated with epidemic and sporadic dysenteries in Eastern India
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DOI：
10.1128/aac.48.2.681-684.2004
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发表时间：
2004-02-01
影响因子：
4.9
通讯作者：
Niyogi, SK
中科院分区：
文献类型：
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作者：
Pazhani, GP;Sarkar, B;Niyogi, SK
2002 年和 2003 年印度东部发生的三起痢疾暴发和散发病例与 1 型志贺氏菌多重耐药菌株有关。在中断 14 年之后，这种病原体重新出现，并改变了抗生素耐药性模式。除氨苄青霉素、复方新诺明、四环素、氯霉素和萘啶酸外，所有新发现的菌株均对诺氟沙星、洛美沙星、培氟沙星和氧氟沙星耐药，并且对环丙沙星的敏感性降低。脉冲场凝胶电泳鉴定出 1 型痢疾沙门氏菌的新克隆，该克隆与最近的爆发和散发病例有关。根据多重耐药性痢疾沙门氏菌1型的空间和时间传播，我们预测这种克隆类型可能会在该地区进一步传播。
Multidrug-resistant strains of Shigella dysenteriae type 1 were implicated in three outbreaks and sporadic cases of dysentery in eastern India in 2002 and 2003. After a hiatus of 14 years, this pathogen reemerged with an altered antibiotic resistance pattern. In addition to ampicillin, co-trimoxazole, tetracycline, chloramphenicol, and nalidixic acid, all the recent strains were resistant to norfloxacin, lomefloxacin, pefloxacin, and ofloxacin and showed reduced susceptibility to ciprofloxacin. Pulsed-field gel electrophoresis identified a new clone of S. dysenteriae type 1 that was associated with the recent outbreaks and sporadic cases. Based on the spatial and temporal spread of multidrug-resistant S. dysenteriae type 1, we predict that this clonal type may spread further in this region.