Engineering Yarrowia lipolytica to produce fuels and chemicals from xylose: A review
Engineering Yarrowia lipolytica to produce fuels and chemicals from xylose: A review
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工程解脂耶氏酵母利用木糖生产燃料和化学品：综述
DOI：
10.1016/j.biortech.2021.125484
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发表时间：
2021
影响因子：
11.4
通讯作者：
Ji Xiao-Jun
中科院分区：
文献类型：
--
作者：
Sun Tao;Yu Yizi;Wang Kaifeng;Ledesma-Amaro Rodrigo;Ji Xiao-Jun
从木质纤维素生物质生产化学品和燃料由于其经济可行性和环境吸引力而具有巨大的潜在工业应用。然而，所利用的微生物必须能够利用木质纤维素水解产物中存在的所有糖，特别是木糖，木糖是地球上第二丰富的单糖。解脂耶氏酵母是从生物质生产各种有价值的产品的良好候选者，但该酵母不能有效地分解木糖。代谢工程的发展为Y. lipolytica作为木糖生物转化为各种增值产品的平台。本文综述了Y.解脂本文综述了Y.进一步介绍了用于生产化学品和燃料的脂解剂。最后，对木质纤维素水解液作为Y.解脂作用进行了讨论。
The production of chemicals and fuels from lignocellulosic biomass has great potential industrial applications due to its economic feasibility and environmental attractiveness. However, the utilized microorganisms must be able to use all the sugars present in lignocellulosic hydrolysates, especially xylose, the second most plentiful monosaccharide on earth.Yarrowia lipolyticais a good candidate for producing various valuable products from biomass, but this yeast is unable to catabolize xylose efficiently. The development of metabolic engineering facilitated the application ofY. lipolyticaas a platform for the bioconversion of xylose into various value-added products. Here, we reviewed the research progress on natural xylose-utilization pathways and their reconstruction inY. lipolytica. The progress and emerging trends in metabolic engineering ofY. lipolyticafor producing chemicals and fuels are further introduced. Finally, challenges and future perspectives of using lignocellulosic hydrolysate as substrate forY. lipolyticaare discussed.