OVARIAN-FUNCTION AFTER SUCCESSFUL BONE-MARROW TRANSPLANTATION IN POSTMENARCHEAL FEMALES
OVARIAN-FUNCTION AFTER SUCCESSFUL BONE-MARROW TRANSPLANTATION IN POSTMENARCHEAL FEMALES
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DOI：
10.1002/mpo.2950110514
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
RAMSAY, NKC
中科院分区：
文献类型：
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作者：
SKLAR, CA;KIM, TH;RAMSAY, NKC
Ovarian function was followed serially in a group of 6 postmenarcheal females after successful bone marrow transplantation (BMT) [for hematologic malignancies]. The patients were between 13 9/12 and 22 6/12 (median 16 5/12) yr of age at the time of BMT and were followed a median of 20 mo. (range 17-45 mo.) posttransplantation. Two subjects received short-term high-dose cyclophosphamide combined with single-dose total lymphoid irradiation (Group I), whereas the remaining 4 were treated with short-term, high-dose chemotherapy plus single-dose total body irradiation (Group II). Group II subjects also received combination chemotherapy prior to BMT. One subject from Group I continues to have regular menses and normal gonadotropin levels, 36 mo. post-BMT. The remaining 5 patients have demonstrated persistently elevated plasma concentrations of LH [luteinizing hormone] and FSH over a 17- to 45-mo. period of time. None of the 4 patients in Group II has menstruated since undergoing BMT. Single-dose radiation combined with short-term, high-dose chemotherapy results in profound ovarian damage in the majority of young women undergoing BMT.
