Distribution of pigment epithelium autofluorescence in retinal disease state recorded in vivo and its change over time
Distribution of pigment epithelium autofluorescence in retinal disease state recorded in vivo and its change over time
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DOI：
10.1007/s004170050186
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发表时间：
1999-01-01
影响因子：
2.7
通讯作者：
Bird, AC
中科院分区：
文献类型：
--
作者：
von R端ckmann, A;Fitzke, FW;Bird, AC
背景：最近发展了一种视网膜色素上皮(RPE)的成像技术，该技术利用了脂褐素产生的固有荧光。本研究的目的是记录各种视网膜疾病患者眼底自发荧光的分布及其随时间的变化。方法：应用激光共聚焦扫描检眼镜对159例(318只眼)各种视网膜疾病患者的眼底自发荧光强度及空间分布进行观察。对30例黄斑营养不良患者和30例老年性黄斑疾病患者进行了为期1~3年的连续检查，以监测眼底自发荧光随时间的变化。结果：在患有视网膜色素变性和视锥细胞营养不良的眼球中，自身荧光缺失与视网膜外部萎缩有很好的空间对应关系。在一些显性和隐性视网膜色素变性和视锥细胞营养不良的患者中，黄斑区可见异常高的背景自体荧光。黄斑水肿区眼底自发荧光异常。大多数视网膜疾病患者的眼底自发荧光显示随着时间的推移而变化。结论：眼底自发荧光可以记录视网膜色素变性和视锥细胞营养不良患者的光感受器细胞丢失区域。如果仅在一些视网膜色素变性患者的存活区域出现异常高的背景自体荧光，该技术可能有助于区分区域性和弥漫性疾病类型。随着时间的推移，眼底自发荧光可能显示变化，也可能保持稳定。
Background: Recently a technique of imaging the retinal pigment epithelium (RPE) has been developed that takes advantages of its intrinsic fluorescence derived from lipofuscin. The purpose of this study was to document the distribution of fundus autofluorescence in patients with various retinal diseases and its change over time. Methods: The intensity and spatial distribution of fundus autofluorescence was documented in 318 eyes from 159 patients with Various retinal diseases using a confocal Laser Scanning Ophthalmoscope. Thirty patients with macular dystrophies and 30 with age-related macular disease underwent serial examinations over a period of 1-3 years in order to monitor the changes over time of fundus autofluorescence. Results: Absent autofluorescence corresponded well spatially with outer retinal atrophy in eyes with retinitis pigmentosa and rod-cone dystrophy. Abnormally high background autofluorescence was seen in the macular region in some patients with dominant and recessive retinitis pigmentosa and rod-cone dystrophies. In areas of macular edema fundus autofluorescence was abnormal. Fundus autofluorescence showed changes over time in most of the eyes with retinal diseases studied. Conclusion: Fundus autofluorescence allows documentation of areas of photoreceptor cell loss in eyes with retinitis pigmentosa and rod-cone dystrophies. If abnormal high background autofluorescence in the surviving areas occurs only in some patients with retinitis pigmentosa, the technique may serve to distinguish the regional from the diffuse type of disease. Over time, fundus autofluorescence may demonstrate change or may remain stable.