On freeze-thaw sequence of vital organ of assuming the cryoablation for malignant lung tumors by using cryoprobe as heat source
On freeze-thaw sequence of vital organ of assuming the cryoablation for malignant lung tumors by using cryoprobe as heat source
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DOI：
10.1016/j.cryobiol.2010.10.157
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发表时间：
2010-12-01
期刊：
影响因子：
2.7
通讯作者：
Lin, Yi-Shan
中科院分区：
文献类型：
--
作者：
Nakatsuka, Seishi;Yashiro, Hideki;Lin, Yi-Shan
对于恶性肺肿瘤的冷冻消融，已经进行了多次冻融过程的试验，我们认为有必要将冻融过程作为一个冻融序列来看待和分析。我们使用针状圆柱形不锈钢探针作为冻融序列的热源，利用探针尖端的焦耳-汤姆逊效应现象，用超高压氩气冷却至-150℃，在猪体内肺中产生序列。在本实验中，我们通过测量温度，使用等温曲线和冻结函数来检验序列。结果表明，第一序列和第二序列的冷冻特性与肝脏和肾脏等非通气器官的冷冻特性有很大不同。在我们对猪肺的实验中，我们认为由于第一次解冻引起的出血渗透到肺实质中，热物性发生了变化，并证实了第二次循环的冻结面积比第一次循环显著扩大（当类似的序列连续重复时，我们称之为循环）。本文提供了这些细节。(C) 2010爱思唯尔公司版权所有。
Regarding cryoablation for the malignant lung tumors, multiple trials of the freeze-thaw process have been made, and we considered it necessary to view and analyze the freeze-thaw process as a freeze-thaw sequence. We caused the sequence in a porcine lung in vivo by using an acicular, cylindrical stainless-steel probe as the heat source for the freeze-thaw sequence and cooling to -150 degrees C with super high-pressure argon gas by causing the Joule-Thomson effect phenomenon at the tip of the probe. In this experiment, we examined the sequence by measuring the temperature and using the isothermal curve and the freezing function. As a result, it was demonstrated that the freezing characteristics considerably differed in the first sequence and the second sequence from those of non-aerated organs such as liver and kidney. In our experiments on porcine lung, thermal properties were considered to change as the bleeding caused by the first thawing infiltrated in the lung parenchyma, and it was confirmed that the frozen area in the second cycle was dramatically enlarged as compared with the first cycle (when a similar sequence is continuously repeated, we say it as cycle). This paper provides these details. (C) 2010 Elsevier Inc. All rights reserved.