EQUIVALENCE OF THE INSULIN SENSITIVITY INDEX IN MAN DERIVED BY THE MINIMAL MODEL METHOD AND THE EUGLYCEMIC GLUCOSE CLAMP
EQUIVALENCE OF THE INSULIN SENSITIVITY INDEX IN MAN DERIVED BY THE MINIMAL MODEL METHOD AND THE EUGLYCEMIC GLUCOSE CLAMP
复制标题
DOI：
10.1172/jci112886
复制
发表时间：
1987-03-01
影响因子：
15.9
通讯作者：
OLEFSKY, JM
中科院分区：
文献类型：
--
作者：
BERGMAN, RN;PRAGER, R;OLEFSKY, JM
进行研究以确定最小模型方法和葡萄糖钳夹是否测量胰岛素作用的等效指数。在10名受试者（体重指数，BMI，21 - 41 kg/m2）中以两种胰岛素（I）输注速率（15和40 mU/min/m2）进行正常血糖葡萄糖钳夹（葡萄糖，G：85% mg/dl）。来自钳夹的胰岛素敏感性指数（SI）在0.15至3.15之间变化（平均值：1.87 ± 0.05）。0.36. times. 10-2 dl/[min/m2]/μ U/ml），并且随着肥胖的增加而线性下降（相对于BMI：r = -0.97; P < 0.001）。来自模拟修改的频繁取样静脉内耐受性试验的SI从0.66变化到7.34 ×。10-4 min-1/μ U/ml，与SIP（钳夹）呈强相关（r = 0.89; P < 0.001）。SI和SIP（钳夹）相似（0.046 ± 0.0001）。0.008对0.037 ±。0.007 dl/min/μ U/ml，P > 0.35）;该关系的斜率与1没有差异（1.05 P > 0.70），并通过原点（P > 0.40）。然而，在配对基础上，由于FSIGT期间肝葡萄糖输出的抑制，SI略微超过SIP（钳夹），不包括在SIP（钳夹）中。这些方法对于评估正常和胰岛素抵抗的非糖尿病受试者的总体胰岛素敏感性是等效的。
Studies were done to determine whether the minimal model approach and the glucose clamp measure equivalent indices of insulin action. Euglycemic glucose clamps (glucose, G: 85% mg/dl) were performed at two rates of insulin (I) infusion (15 and 40 mU/min per m2) in 10 subjects (body mass index, BMI, from 21 to 41 kg/m2). Insulin sensitivity index (SI) from clamps varied from 0.15 to 3.15 (mean: 1.87 .+-. 0.36 .times. 10-2 dl/[min per m2] per .mu.U/ml), and declined linearly with increasing adiposity (versus BMI: r = -0.97; P < 0.001). SI from modeling the modified frequently sampled intravenous tolerance test varied from 0.66 to 7.34 .times. 10-4 min-1 per .mu.U/ml, and was strongly correlated with SIP(clamp) (r = 0.89; P < 0.001). SI and SIP(clamp) were similar (0.046 .+-. 0.008 vs. 0.037 .+-. 0.007 dl/min per .mu.U/ml, P > 0.35); the relation had a slope not different from unity (1.05 P > 0.70) and passed through the origin (P > 0.40). However, on a paired basis, SI exceeded SIP(clamp) slightly, due to inhibition of hepatic glucose output during the FSIGT, not included in SIP(clamp). These methods are equivalent for assesment of overall insulin sensitivity in normal and insulin-resistant nondiabetic subjects.