Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis
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DOI：
10.1002/mrm.10389
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发表时间：
2003-03-01
影响因子：
3.3
通讯作者：
Dahlberg, L
中科院分区：
文献类型：
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作者：
Tiderius, CJ;Olsson, LE;Dahlberg, L
软骨的延迟对比增强MRI（dGEMRIC）是一种研究体内软骨糖胺聚糖（GAG）含量的非侵入性技术。本研究评估了dGEMRIC在放射学检查前退行性软骨变化患者中的作用。纳入了15例患者（年龄35-70岁）的17个膝关节，关节镜下证实内侧或外侧股骨间室软骨变化（软化和纤维化）、膝关节疼痛和正常负重X线片。静脉注射Gd-DTPA（2-）0.3 mmol/kg体重后1.5 h和3 h分别行MRI（1.5 T）检查。使用五组涡轮反转恢复图像在内侧和外侧股骨软骨中的感兴趣区域中进行T测量。对比前，病变室的R-1（R-1 = 1/T-1，1/s）略低于参考室，表明水合作用增加（P = 0.01）。对比后，病变室的R-1分别在1.5小时、3.45 +/- 0.90和2.64 +/- 0.58（平均SD）时高于参考室（P < 0.01），3小时时分别为2.94 +/- 0.60和2.50 +/- 0.37（P = 0.01）。在病变软骨中，造影剂的洗脱速度更快，如在1.5小时时比在3小时时在病变隔室中的R-1更高所示，但在参考隔室中并非如此。总之，dGEMRIC可以在1.5小时比3小时更高的灵敏度鉴定早期软骨疾病中的GAG损失。
Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Seventeen knees in 15 patients (age 35-70) with arthroscopically verified cartilage changes (softening and fibrillations) in the medial or lateral femoral compartment, knee pain, and normal weight-bearing radiography were included. MRI (1.5 T) was performed precontrast and at 1.5 and 3 hr after an intravenous injection of Gd-DTPA(2-) at 0.3 mmol/kg body weight. T, measurements were made in regions of interest in medial and lateral femoral cartilage using sets of five turbo inversion recovery images. Precontrast, R-1 (R-1 = 1/T-1, 1/s) was slightly lower in diseased compared to reference compartment, indicating increased hydration (P = 0.01). Postcontrast, R-1 was higher in diseased than in reference compartment at 1.5 hr, 3.45 +/- 0.90 and 2.64 +/- 0.58 (mean SD), respectively (P < 0.01), as well as at 3 hr, 2.94 +/- 0.60 and 2.50 +/- 0.37, respectively (P = 0.01). The washout of the contrast medium was faster in diseased cartilage as shown by a higher R-1 at 1.5 than at 3 hr in the diseased but not in the reference compartment. In conclusion, dGEMRIC can identify GAG loss in early stage cartilage disease with a higher sensitivity at 1.5 than 3 hr. (C) 2003 Wiley-Liss, Inc.