Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy
Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy
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两亲性 BODIPY 染料聚集在聚合物胶束中，用于波长依赖性光诱导癌症治疗
DOI：
10.1039/d0tb00609b
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发表时间：
2020
影响因子：
7
通讯作者：
Guo Zhengqing
中科院分区：
文献类型：
--
作者：
Yan Ziling;Wang Mengya;Shi Mengke;He Yang;Zhang Yi;Qiu Shihong;Yang Hong;Chen Huabing;He Hui;Guo Zhengqing
有机小分子染料的近红外（NIR）光响应纳米颗粒由于其固有的优点（包括明确的结构、高纯度和良好的再现性）而具有作为用于临床翻译的光疗染料（PD）的巨大前景。然而，它们在开发具有非凡光转换的光稳定NIR PD以用于高效光疗方面的成功有限。在本文中，我们已经描述了聚合物胶束（胶束）内的两亲性BODIPY染料聚集体作为在NIR照射下用于双重合作光疗的有效双功能PD。胶束具有强的近红外吸收、高的光稳定性和良好的非辐射跃迁，从而在近红外光照射下表现出显著的单线态氧生成和光热效应。此外，胶束还具有较好的细胞摄取、有效的胞浆转运以及增强肿瘤蓄积的作用。由于这些优点的结合，胶束显示出作为光诱导癌症治疗的双功能PD的临床潜力。因此，这项工作提供了一个简单的策略，利用先进的PD的实际光疗应用。
Near-infrared (NIR) light-responsive nanoparticles of organic small-molecule dyes hold great promise as phototherapeutic dyes (PDs) for clinical translation due to their intrinsic merits, including well-defined structure, high purity, and good reproducibility. However, they have been explored with limited success in the development of photostable NIR PDs with extraordinary photoconversion for highly effective phototherapy. Herein, we have described amphiphilic BODIPY dye aggregates within the polymeric micelles (Micelles) as potent bifunctional PDs for dually cooperative phototherapy under NIR irradiation. Micelles possessed an intensive NIR absorption, high photostability, and favorable non-radiative transition, thereby exhibiting both remarkable singlet oxygen generation and photothermal effect under NIR light irradiation. Besides, Micelles had preferable cellular uptake, effective cytoplasmic drug translocation as well as enhanced tumor accumulation. Owing to the combined virtues, Micelles showed clinical potential as bifunctional PDs for photo-induced cancer therapy. This work thus provides a facile strategy to exploit advanced PDs for practical phototherapeutic applications.