Breakdown of cortical effective connectivity during sleep
Breakdown of cortical effective connectivity during sleep
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DOI：
10.1126/science.1117256
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发表时间：
2005-09-30
期刊：
影响因子：
56.9
通讯作者：
Tononi, G
中科院分区：
文献类型：
--
作者：
Massimini, M;Ferrarelli, F;Tononi, G
当我们入睡时，意识会消失，但大脑仍保持活跃。为什么会这样呢？为了研究大脑皮质信息传递的变化是否起作用，我们使用了。他在接受经颅磁刺激和高密度脑电图的同时，询问一个皮质区域(运动前区域)的激活是如何传递到大脑的其他部分的。在安静的清醒状态下，刺激部位的初始反应(类似于15毫秒)紧随其后的是一系列波，这些波移动到几厘米外相连的皮质区域。在非快速眼动睡眠中，最初的反应较强，但很快就消失了，不会扩散到刺激部位之外。因此，在陡峭的某些阶段，意识的衰退可能与皮质有效连接的中断有关。
When we fall asleep, consciousness fades yet the brain remains active. Why is this so? To investigate whether changes in cortical information transmission play a role, we used. transcranial magnetic stimulation together with high-density electroencephalography and asked how the activation of one cortical area (the premotor area) is transmitted to the rest of the brain. During quiet wakefulness, an initial response.(similar to 15 milliseconds) at the stimulation site was followed by a sequence of waves that moved to connected cortical areas several centimeters away. During non-rapid eye movement sleep, the initial response was stronger but was rapidly extinguished and did not propagate beyond the stimulation site. Thus, the fading of consciousness during certain stages of steep may be related to a breakdown in cortical effective connectivity.