Bayesian choice among Markov models of ion channels using Markov chain Monte Carlo
Bayesian choice among Markov models of ion channels using Markov chain Monte Carlo
复制标题
使用马尔可夫链蒙特卡罗在离子通道马尔可夫模型中进行贝叶斯选择
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
P. Green
中科院分区：
文献类型：
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作者：
M. E. A. Hodgson;P. Green
Hodgson提出了一种贝叶斯离子通道分析方法，使用通道动力学的交替更新模型和自回归过程来模拟膜片钳噪声。由此产生的后验计算的可逆跳马尔可夫链蒙特卡罗方法。我们在这里的重点是将这种分析扩展到物理上更现实的信道动态隐马尔可夫模型。这里，通道的状态被划分为具有相同电导的状态的类别，使得膜片钳记录仅提供关于聚集过程的信息。这种信息的丢失增加了对底层马尔可夫链进行结构推断的挑战。我们目前的研究，涉及几个简单的模型之间的歧视，服务于给一些指示，更一般的马尔可夫模型测定离子通道的可行性。
Hodgson formulates a Bayesian method of ion–channel analysis, using an alternating renewal model of channel kinetics and an autoregressive process to model patch–clamp noise. The resulting posterior is computed by a reversible jump Markov chain Monte Carlo method. Our focus here is on extending this analysis to the more physically realistic hidden Markov models of channel dynamics. Here, the states of the channel are partitioned into classes of states having the same conductance, so that patch–clamp recording is informative only about the aggregated process. This loss of information increases the challenge of making structural inference about the underlying Markov chain. The study we present, involving discrimination between a few simple models, serves to give some indication as to the feasibility of more general Markov model determination for ion channels.
DOI：
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发表时间：
1997
期刊：
Journal of the royal statistical society series b-methodological
影响因子：
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作者：
S. Richardson;P. Green;Christian P. Robert;M. Aitkin;David R. Cox;Matthew Stephens;A. Polymenis;W. Gilks;A. Nobile;M. Hodgson;Anthony O'Hagan;N. Longford;A. Dawid;Anthony C. Atkinson;J. Bernardo;J. Besag;Stephen Brooks;S. Byers;A. Raftery;G. Celeux;R. Cheng;W. B. Liu;Yung-Hsin Chien;Edward I. George;N. Cressie;H.-C. Huang;M. Gruet;S. C. Heath;C. Jennison;Andrew B. Lawson;Allan Clark;Geoffrey J. McLachlan;D. Peel;K. Mengersen;A. George;Anne Philippe;Kathryn Roeder;Larry Wasserman;Peter Schlattmann;D. Böhning;D. M. Titterington;H. Tong;M. West
通讯作者：
S. Richardson;P. Green;Christian P. Robert;M. Aitkin;David R. Cox;Matthew Stephens;A. Polymenis;W. Gilks;A. Nobile;M. Hodgson;Anthony O'Hagan;N. Longford;A. Dawid;Anthony C. Atkinson;J. Bernardo;J. Besag;Stephen Brooks;S. Byers;A. Raftery;G. Celeux;R. Cheng;W. B. Liu;Yung-Hsin Chien;Edward I. George;N. Cressie;H.-C. Huang;M. Gruet;S. C. Heath;C. Jennison;Andrew B. Lawson;Allan Clark;Geoffrey J. McLachlan;D. Peel;K. Mengersen;A. George;Anne Philippe;Kathryn Roeder;Larry Wasserman;Peter Schlattmann;D. Böhning;D. M. Titterington;H. Tong;M. West