Enabling respiratory control after severe chronic tetraplegia: an exploratory case study
Enabling respiratory control after severe chronic tetraplegia: an exploratory case study
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DOI：
10.1152/jn.00320.2020
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发表时间：
2020-09-01
影响因子：
2.5
通讯作者：
Edgerton, V. Reggie
中科院分区：
文献类型：
--
作者：
Gad, Parag;Kreydin, Evgeniy;Edgerton, V. Reggie
呼吸功能障碍是脊髓损伤(SCI)对患者和照顾者生活质量影响最大的影响因素之一。此外。呼吸困难影响了患者可能经历的康复程序。经皮电脊髓神经调制(Tescon)是瘫痪后恢复和训练脊髓神经回路的一种新方法。我们证明，颈髓上的急慢性Tescon疗法对慢性四肢瘫痪患者的呼吸和咳嗽能力有积极的影响。此外，我们发现，呼吸和咳嗽能力的改善不仅在Tescon存在的情况下观察到，而且在Tescon停用后持续几天。NEW&值得注意的非侵入性脊髓神经调节改善了严重和完全四肢瘫痪患者的呼吸和咳嗽。
Respiratory dysfunction is one of the most debilitating effects of spinal cord injury (SCI) impacting the quality of life of patients and caregivers. In addition. breathing difficulties impact the rehabilitation routine a patient may potentially undergo. Transcutaneous electrical spinal cord neuromodulation (TESCoN) is a novel approach to reactivate and retrain spinal circuits after paralysis. We demonstrate that acute and chronic TESCoN therapy over the cervical spinal cord positively impacts the breathing and coughing ability in a patient with chronic tetraplegia. In addition, we show that the improved breathing and coughing ability are not only observed in the presence of TESCoN but persisted for a few days after TESCoN was stopped.NEW & NOTEWORTHY Noninvasive spinal neuromodulation improves breathing and coughing in a patient with severe and complete tetraplegia.