Quantification of breast density with dual energy mammography: an experimental feasibility study.
Quantification of breast density with dual energy mammography: an experimental feasibility study.
复制标题
双能乳房X线照相术定量乳房密度：实验可行性研究。
DOI：
10.1118/1.3284975
复制
发表时间：
2010
期刊：
影响因子：
3.8
通讯作者：
Molloi,Sabee
中科院分区：
文献类型：
--
作者：
Ducote,JustinL;Molloi,Sabee
乳腺密度，即乳腺腺体组织的百分比，已被证明是乳腺癌风险的一个强有力的指标。一种定量的方法来测量乳腺密度与双能量乳腺X射线摄影使用physical phanomaly. MethodsThe双能量乳腺X射线摄影系统使用钨阳极X射线管与铑束过滤器的低能量图像和铜束过滤器的高能量图像。利用均匀厚度的腺体和脂肪等效体模对双能量基分解算法进行了标定。四种不同的体模研究被用来评估该技术。第一项研究由厚度为2.5 - 8.5 cm的体模组成，步长为0.5 cm，可变密度以平均值28%为中心。第二项研究包括固定厚度为4.0 cm的体模，密度范围为0%至100%，增量为12.5%。第三项研究包括4.0 cm厚的体模，密度分别为25%、50%和75%，在三个面积尺寸（约62.5、125和）下成像，以评估乳房尺寸对密度测量的影响。第四项研究包括阶梯体模，旨在更接近地模拟女性乳房的形状，最大厚度为3.0至7.0 cm，固定密度为50%。结果乳腺密度测量的RMS误差对于变厚度体模为0.44%，对于变密度体模为0.64%，对于不同面积大小的体模为2.87%，4.63%结论：双能量乳腺X线摄影可以用于乳房的X线检查，以测量乳房密度，RMS误差约为5%。
PurposeBreast density, the percentage of glandular breast tissue, has been shown to be a strong indicator of breast cancer risk. A quantitative method to measure breast density with dual energy mammography was investigated using physical phantoms.MethodsThe dual energy mammography system used a tungsten anode x‐ray tube with a rhodium beam filter for low energy images and a copper beam filter for high energy images. Glandular and adipose equivalent phantoms of uniform thickness were used to calibrate a dual energy basis decomposition algorithm. Four different phantom studies were used to evaluate the technique. The first study consisted of phantoms with thicknesses of 2.5–8.5 cm in 0.5 cm steps with variable densities centered at a mean of 28%. The second study consisted of phantoms at a fixed thickness of 4.0 cm, which ranged in densities from 0% to 100% in increments of 12.5%. The third study consisted of 4.0 cm thick phantoms at densities of 25%, 50% and 75% each imaged at three areal sizes, approximately 62.5, 125, and , in order to assess the effect of breast size on density measurement. The fourth study consisted of step phantoms designed to more closely mimic the shape of a female breast with maximal thicknesses from 3.0 to 7.0 cm at a fixed density of 50%. All images were corrected for x‐ray scatter.ResultsThe RMS errors in breast density measurements were 0.44% for the variable thickness phantoms, 0.64% for the variable density phantoms, 2.87% for the phantoms of different areal sizes, and 4.63% for step phantoms designed to closely resemble the shape of a breast.ConclusionsThe results of the phantom studies indicate that dual energy mammography can be used to measure breast density with an RMS error of approximately 5%.