Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases
Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases
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1型和2型糖尿病与七种心血管疾病的发病率
DOI：
10.1016/j.ijcard.2018.03.099
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发表时间：
2018-07-01
影响因子：
3.5
通讯作者：
Wolk, Alicja
中科院分区：
文献类型：
--
作者：
Larsson, Susanna C.;Wallin, Alice;Wolk, Alicja
背景：1型糖尿病（T1 DM）与特定心血管疾病（CVD）之间的关系尚不确定。此外，2型糖尿病（T2 DM）与主动脉瓣狭窄、房颤、腹主动脉瘤和脑出血风险相关的数据很少且不确定。我们研究了T1 DM和T2 DM与七种CVD结局发生率的相关性：本研究包括来自两个以人群为基础的前瞻性队列的71,483名瑞典成年人。T1 DM和T2 DM的诊断以及心血管事件的发生通过与基于人群的登记数据的关联来确定。（风险比[HR] 3.26; 95%置信区间[CI] 2.47-4.30），心力衰竭（HR 2.68; 95% CI 1.76-4.09）和缺血性卒中（HR 2.61; 95% CI 1.80-3.79）。在T2 DM患者中也观察到心肌梗死、缺血性卒中和心力衰竭的风险增加，并且相关性的程度随着T2 DM持续时间的延长而增加。T2 DM还与主动脉瓣狭窄风险增加（HR 1.34; 95% CI 1.05-1.71）以及腹主动脉瘤（HR 0.57; 95% CI 0.40-0.82）和脑出血（HR 0.51; 95% CI 0.30-0.88）风险降低相关。只有长期T2 DM（≥ 20年）与房颤风险增加相关（HR 1.44; 95%CI 1.02-2.04）。结论：T1 DM和T2 DM与主要心血管疾病结局风险增加相关。试验注册：瑞典男性队列和瑞典乳腺X线摄影队列分别在clinicaltrials.gov注册为NCT 01127711和NCT 01127698。(C)2018作者由爱思唯尔公司出版
Background: The association between type 1 diabetes mellitus (T1DM) and specific cardiovascular diseases (CVD) is uncertain. Furthermore, data on type 2 diabetes mellitus (T2DM) in relation to risk of aortic valve stenosis, atrial fibrillation, abdominal aortic aneurysm, and intracerebral hemorrhage are scarce and inconclusive. We examined the associations of T1DM and T2DM with incidence of seven CVD outcomes.Methods: This study comprised 71,483 Swedish adults from two population-based prospective cohorts. T1DM and T2DM diagnosis and incident CVD cases were ascertained through linkage with the population-based registers.Results: T1DM was associated with myocardial infarction (hazard ratio [HR] 3.26; 95% confidence interval [CI] 2.47-4.30), heart failure (HR 2.68; 95% CI 1.76-4.09), and ischemic stroke (HR 2.61; 95% CI 1.80-3.79). Increased risk of myocardial infarction, ischemic stroke, and heart failure was also observed in T2DM patients and the magnitude of the associations increased with longer T2DM duration. T2DM was also associated with an increased risk of aortic valve stenosis (HR 1.34; 95% CI 1.05-1.71) and with lower risk of abdominal aortic aneurysm (HR 0.57; 95% CI 0.40-0.82) and intracerebral hemorrhage (HR 0.51; 95% CI 0.30-0.88). Only long-term T2DM(>= 20 years) was associated with an increased risk of atrial fibrillation (HR 1.44; 95% CI 1.02-2.04).Conclusion: T1DM and T2DM are associated with increased risk of major CVD outcomes. Trial registration: The Cohort of Swedish Men and the Swedish Mammography Cohort are registered at clinicaltrials.gov as NCT01127711 and NCT01127698, respectively. (C) 2018 The Authors. Published by Elsevier B.V.